International Journal of Cardiovascular and Cerebrovascular Disease(CEASE PUBLICATION)  

International Journal of Cardiovascular and Cerebrovascular Disease is an international peer-reviewed journal that publishes original and high-quality research papers in all areas of cardiovascular and cerebrovascular disease. As an important academic exchange platform, scientists and researchers can know the most up-to-date academic trends and seek valuable primary sources for reference.

After consideration, we have decided to cease publication of this journal at the end of 2022. This journal will no longer accept submissions and subscriptions from 2023. All published articles will remain available in Archive at

ISSN: 2331-9887 (Print)

ISSN: 2331-9895 (Online)

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Horizon Research Publishing(HRPUB) publishes peer-reviewed, open access journals covering a wide range of academic disciplines. Before manuscript submission, please read and follow these instructions carefully; doing so will ensure that the publication of your manuscript is as rapid and efficient as possible.
Manuscript Submission
Horizon Research Publishing accepts manuscripts prepared in the following formats: LaTex and Microsoft Word (2003 or above) submit via Online Manuscript Tracking System. For new users, you will need to register. After registration, you can continue your submission and track the status of your manuscript afterwards. If online submission is not successful due to some technical reasons, you can submit the manuscript to us via email at

Manuscript Template
Authors may download a MS Word template by clicking here. For the LaTex template, click here to download.

Types of Articles
The journal welcomes submission of full-length research articles, review articles, and critical analysis articles.

Manuscripts submitted to our journals must be written in English. Papers accepted for publication vary from 5 to 20 pages in two-column format (at least 3000 words but no more than 10000 words, inclusive of references). The main text usually can be divided into separated sections, organized by Introduction, Materials and Methods, Results, Discussion, Conclusion, Acknowledgement, Conflict of Interest, Appendix and Reference. However, this journal does not accept any submissions generated with AI or AI-assisted technologies, nor can AI or AI-assisted technologies be credited or cited as an author.

Paper Title
A title of no more than 20 words should be brief, specific, and informative.

Author Details
Full name for all authors should be given; The names of multiple authors are separated by a comma; Provide the full affiliation for each author including academic affiliation (or postal address), city, postcode, country, e-mail(optional); If multiple authors have contributed to the article, details of the corresponding author should be clear. Email address is compulsory for the corresponding author.

The abstract should be written as a continuous paragraph with 200-350 words and recapitulatively state the background of the research, purpose, methodologies, principal results, major conclusions and its contributions to the field. It should emphasize new or important aspects of the study. Research limitations/implications, practical implications, and social implications should also be included, if relevant to your manuscripts.

3-10 keywords which can accurately reflect the theme of the article should be included for indexing.

Provide a brief overview of the scope and relevance of the research, especially with regard to previous advancements in related fields

Materials and Methods
Present the research design, research type, research duration, inclusion/exclusion criteria, choice of subjects, etc. Describe the methodology completely, including sample collection, processing, lab analysis, statistical tests used for data analysis etc. Use section headings/subheadings in a logical order to entitle each category or method . (e.g. 1, 2; 1.1, 2.1; 1.1.1, 2.1.1…etc)

Present and illustrate your findings objectively and concisely, if appropriate, with figures/ tables. In the main text, describe each of your results by a particular observation.

Provide an interpretation of your results and make comparisons with other studies. The significance of findings should be clearly described. If your results differ from your expectations, explain why that may have happened. If your results agree, then describe the theory that the evidence supported.

The main conclusions of the experimental work should be presented. The contribution of the work to the scientific research and its economic implications should be emphasized.

An appendix may be included (and is often helpful) in mathematical or computational modeling.

The acknowledgements section is where you may wish to thank people indirectly involved with the research (e.g., technical support; loans of experimental facilities; comments or suggestions during the creation of the manuscript). However, it is important that anyone listed here knows in advance of your acknowledgement of their contributions. Do not include dedications.

Every table must have a unique title placed at the top. Titles should be clear and concise, and they should not be complete sentences.

TABLE Format
Table tools in Microsoft Word are strongly recommended for inserting a table. It’s necessary to avoid tables created with the tab key.

TABLE Numbering & Citation
Tables in the main body of the text should be numbered and cited consecutively according to their appearance in the text.

FIGURE Caption
Each figure should have a caption. The caption should be concise and typed separately, not on the figure area; If figures have parts (for example, A and B), make sure all parts are explained in the caption.

FIGURE Numbering & Citation
All figures are to be sequentially numbered with Arabic numerals. Figures should always be cited in text in consecutive numerical order.

FIGURE Resolution
Figures must be created at a minimum resolution of 300 dpi. For fuzzy or jagged figures, authors are required to replace it or send the original figure file to us for reproduction.

The equation number should be placed in parentheses to the right of the equation. E.g. Hn+1(1/n+1, 1/n+1, …, 1/n+1) (1); Do not create equations as pictures. Use MathType or insert symbols as normal text.

EQUATION Numbering & Citation
Equations should be numbered consecutively with Arabic numerals to avoid ambiguities, if they will be referred to in text. Citation for an equation should be made by using "(1)," not "Eq. (1)" or "equation (1)," except at the beginning of a sentence: "Equation (1) is…"

(1). All sources cited in text must appear in the reference list and all items in the reference list must be cited in text.
(2). All references should be listed numerically in the order they've been cited within the paper. At the beginning of each reference, the bracketed number should be included.

REFERENCES In-Text Citation Format
References are simply cited with the consistent reference number in square brackets. Do not set references number as superscript number. Do not use "Ref. [3]" or "Reference [3]" except at the beginning of a sentence, e.g. "Reference [3] shows …"
A. Single Reference
If the author's name appears in the text, place the reference number immediately after the name. E.g. Peter[10] found an innovative scientific phenomenon.
B. Multiple References
(1). Put two numbers in numerical order and separate them by commas but no spaces. E.g.: [2,3] or [2], [3]
(2). Indicate three or more consecutive reference numbers by using the following format. E.g.: [1], [3], [5]; [1] – [5] or [1, 3, 5]; [1-5]

Authors are requested to check all references for completeness, including author names, paper title, journal heading, Volume, Number., pages for journal citations, Year, DOI (or URL if possible). (Please note that the DOI should be placed after the URL and end with a period.)
All author names, "Title," Journal title, vol., no., pp. xxx–xxx., Year, DOI (or URL)
[1] Clarke A., Mike F., S. Mary, "The Use of Technology in Education," Universal Journal of Educational Research, vol. 1, no. 1, pp. 1–10, 2015. DOI: 10.13189/ujer.2015.010829
All author names, "Title of chapter in the book," in Title of the Published Book, (xth ed. if possible), Abbrev. of Publisher, Year, pp. xxx–xxx.
[1] Tom B, Jack E, R. Voss, "The Current Situation of Education," in Current Situation and Development of Contemporary Education, 1st ed, HRPUB, 2013, pp. 1-200.
Conference Papers
All author names, "Title," Conference title, (location of conference is optional), (Month and day(s) if provided) Year, pp., (DOI or URL, if possible)
[1] David H., Tim P., "The Use of Technology in Teaching," The Third International Conference, LA, USA, Jul., 2013, pp. 19-23. (The year may be omitted if it has been given in the conference title) (DOI or URL, if possible).
All author names, "Page Title." Website Title. Web Address (retrieved Date Accessed).
[1] Partson K., Joe L., "The Use of Technology in Teaching", US News, (accessed Jan. 1, 2013).

Manuscript Review
Initial Screening (7 working days)
Submitted manuscripts will be initially screened by the editorial assistant for completeness and to determine if the manuscript meets the general criteria for the journal from the following aspects:
(1). The manuscripts should be within the scope of a specific journal.
(2). The manuscripts should be of acceptable quality.
(3). The manuscripts should compliant with the journal's instruction for authors.
(4). The title should be as brief as possible with no more than 20 words.
(5). All authors of a manuscript should include their full names. Provide the full affiliation for each author including Department, Faculty, University, City, Zip Code, State.
(6). A good abstract (200-350 words) should provide the essence of the manuscript in a concise paragraph.
(7). 3-10 keywords should be included for indexing.
(8). A manuscript should be well organized into logical sections. The preferred order of contents should be as follows: Introduction, Methodology, Results, Discussion and Conclusion. Acknowledgements, Appendix, References.
(9). All references should be numbered sequentially in the text and listed in the same numerical order in the reference section. The section of references should be more than eight.
(10). All references should be cited in the right citation style.
(11). Figures and tables used in the manuscripts should be relevant to the Task, with informative content and high resolution.
(12). Each figure should be numbered consecutively with Arabic numerals and accompanied by an appropriate descriptive caption.
(13). Each table should be numbered consecutively and labeled with an explanatory title.
(14). Equations should be generated using the equation editor embedded in MS Word or Math Type.
(15). Submissions vary from 5 to 20 pages in two-column format (at least 3000 words but no more than 10000 words, inclusive of references).
(16). The Manuscripts must be written in English. The clarity and fluency of the language should be ensured.

The editorial office will decide to: (a) send the manuscript out for double blind review, (b) request initial revisions prior to the double blind review process, or (c) reject the manuscript. The initial screening result will be sent to the corresponding author via email within 7 working days.

Peer Review (3-4 Weeks)
The journal employs a double-blind peer review system, which is the most important aspect of the publication process of an article. Each manuscript passing initial screening will be subjected to rigorous and anonymous peer-review by a minimum of 2 peer reviewers. Referees who review a manuscript remain unknown to the authors. The journal’s independent status ensures a submission acceptance rate based on merit and not favor, bias, or personal preference. All the reviewers send the editorial assistant a detailed report with their comments and recommendations on the manuscript. Authors receive reviewers’ comments and recommendations from the editorial assistant and they never enter in contact with reviewers. Usually, reviewers will complete their reviews within 3-4 weeks. The reviewers make a recommendation to accept, revise, or reject a manuscript based on the scientific merit and technical quality of the studies reported.

Revision after Peer Review (15 working days)
Authors are required to revise the manuscripts according to the comments of the reviewers and answer all questions raised by reviewers in a cover letter. Any revisions should be marked out. The revised manuscripts and cover letters are required to be sent to us via email in MS Word or LaTex format within 15 working days. If you are submitting in LaTeX, please convert the files to PDF beforehand (you will also need to send your LaTeX source files together with the PDF). Upon resubmission, the academic editor may choose to return the manuscript to the reviewers for additional review, or may render a decision of accepting, recommending modification or rejecting based on his/her personal expertise.

Plagiarism Policy
Plagiarism, an action of taking other people's language, thoughts, ideas, or expressions as one's own original work is considered academic dishonesty and a violation of journalistic ethics. Reusing portions of one's own published or copyrighted work in their new publications is self-plagiarism. A breach of copyright law or punishment by legal action may be involved in plagiarism. All manuscripts submitted to our journals will be screened by a plagiarism detection software. Plagiarism tools, such as CrossCheck/iThenticate, Turnitin etc. can be used for plagiarism detection.
To avoid plagiarism, authors confirm that:
1. I/We understand plagiarism is against the professional ethics;
2. Quoted verbatim texts are marked clearly with quotation marks;
3. Quotation sources are referenced clearly both in the text and in the Reference section;
4. Citing the source of equations, figures or tables properly with the permission from the original author or copyright holder;
5. Avoid self-plagiarism; do not copy portions of one's own published or copyrighted work without proper citation;
6. No copyrighted materials are used in the manuscript without permission;
7. The manuscript is free from plagiarism and has not been published previously;
8. I/We will take full responsibility for the opinion expressed in the paper and settling in all disputes arising from using any copyrighted materials in the manuscript without proper permission.
The author will be required to clarify regarding the plagiarized manuscript within one week if it is found to be suspected of plagiarism during any stages even after publication. Without a reasonable and timely explanation, the manuscript will be automatically rejected or removed from the system and any manuscripts submitted by the same author will not be accepted.

Acceptance Letters (Within 7 working days)
After the revision process, qualified manuscripts will be accepted for publication. The Acceptance Letters will be sent to the corresponding authors within 7 working days.

Article Charge Processing
In an open access model, we promise that readers don’t pay for the subscription fee to access online published articles. For authors, only some fundamental costs like editing, production and peer- review are included to maintain normal operations of our company. These Article Processing Charges(APC) are only used to support publishers to make the published articles freely available to all readers. The payment option in our Online Manuscript Tracking System is disabled by default for each manuscript and it is only enabled when the manuscript has been accepted for publication. In that case, authors do not need to make payment until their manuscripts have been reviewed and accepted for publication. The charge is a flat and single charge without additional costs.

Proof Reading (Within 3 working days)
Proofreading is the final stage of the editing process. HRPUB will conduct efficient and thorough proofreading process for all the accepted manuscripts. The proofs will be sent to the authors for final confirmation and authors get the chance of checking before publication. Proofs should be checked and returned within 3 days, or they will be regarded as the final version.

Publication Notification (A Week after Publication)
After the article is released on the journal’s website, a publication notification will be sent to the corresponding author with links to the article.

Concurrent Submissions
Authors are limited to having three manuscripts under review at any point in time, so that sufficient diversity within the authorship of the journal can be ensured. If an author already has three manuscripts under review in the journal, they will need to wait until the review process of at least one of these manuscripts is complete before submitting another manuscript for consideration.

License and Permission
Under the premise of legal publishing, the corresponding author is required to grant an exclusive license to Horizon Research Publishing on behalf of all authors.
Once the submitted paper is accepted for publication, authors will be invited to fill in an electronic copyright transfer form. If the form hasn’t been received along with the final revised manuscript, the publication of your manuscript may be postponed.
Manuscripts submitted for publication must be original, previously unpublished, and not under consideration for publication elsewhere. If previously published materials written by others have to be used, the copyright-owner’s permission must be obtained prior to submission. The author takes the responsibility for checking whether material submitted is subject to copyright or ownership rights. To avoid delay in publication, it would be better for authors to start obtaining all the permissions as early as possible. If in any doubt about the copyright , apply for permission. HRPUB Publications cannot publish material from other publications without permission. If any unpermitted material used in the article is found, the article will be rejected or removed from our website, even if it has already been published.

Authorship of a manuscript should be limited to authors who have made significant contributions.
ICMJE recommends that authorship be based on the following four criteria.
1. Substantial contributions to the conception or design of the work; or the acquisition, analysis, or interpretation of data for the work;
2. Drafting the work or revising it critically for important intellectual content;
3. Final approval of the version to be published;
4. Agreement to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.

Changes in Authorship
Authors should decide upon the correct name and order of authors before submitting their manuscripts to the journal. Any addition, deletion or rearrangement of author names in the authorship list should be made only before the manuscript has been accepted and only approved by the journal editor. Following the COPE guidelines, the corresponding author should explain the reason for changing authorship to journal editor first. Then, request to change authorship will be carefully reviewed by the journal editor and Editorial Board members. The authorship can only be changed with the Publisher's consent.

All the open access articles published by HRPUB will be immediately free for everyone to read, copy, download and distribute under the terms of the Creative Commons Attribution License (CC BY) or the Creative Commons Attribution-NonCommercial License (CC BY-NC). Authors retain all copyright interest or it is retained by other copyright holder, as appropriate and agree that the manuscript remains permanently open access in HRPUB's site under the terms of the Creative Commons License (CC BY or CC BY-NC). HRPUB shall have the right to use and archive the content for the purpose of creating a record and may reformat or paraphrase to benefit the display of the record. Reuse permission depends on authors' choice of the user licenses - CC BY or CC BY-NC.

If authors want to appeal a decision, they are required to contact us via email at and explain in detail reasons for any complaints or the appeal. Appeals will only be considered when a reviewer or editor is thought to have a significant error or bias, or when the objectivity is compromised by a documented competing interest. While under appeal, the manuscript remains under formal consideration and hence should not be submitted for consideration elsewhere. Usually, the processing of appeals will take no more than 15 workdays. HRPUB has the right to make a final decision and second appeals will not be considered. After the processing of appeals is completed, the manuscript can be submitted to other publishers. Appeals regarding any published materials will only be accepted within 12 months from the first publication date.

Duties / Responsibilities of Authors
1. All manuscripts must be the original work of authors and not plagiarism.
2. Authorship of a manuscript should be limited to authors who have made significant contributions.
3. Authors must properly and accurately acknowledge the work of others.
4. Authors should disclose any financial or other substantive conflict of interest that might influence the results or interpretation of their manuscript and acknowledge individuals or organizations that have provided financial support for research.
5. Authors may be asked to provide the raw data in connection with manuscripts for editorial review, and should prepare to provide public access to such data if possible.
6. All manuscripts must be previously unpublished, and not under consideration for publication elsewhere.

Open Access Policy
Open access is a publishing model for scholarly communication which enables the dissemination of research articles to the global community without any cost and any form of restriction. It is the practice of providing unrestricted access to peer-reviewed academic journal articles via the internet and is increasingly being provided to scholarly monographs and book chapters. All original research papers published by HRPUB are available freely and accessible online immediately after publication. Readers are free to read, copy, download and distribute under the Creative Commons Attribution License (CC BY) or the Creative Commons Attribution-NonCommercial License (CC BY-NC). For reuse permission, please consult the publisher. Authors can benefit from the open access publication model a lot from the following aspects:
● High Availability and High Visibility-free and unlimited accessibility of the publication over the internet without any restrictions.
● Rigorous peer review of research papers----Fast, high-quality double blind peer review.
● Faster publication with less cost----Papers published on the internet without any subscription charge.
● Higher Citation-- open access publications are more frequently cited.

If you have any questions or concerns, please feel free to contact us via email at