International Journal of Biochemistry and Biophysics Vol. 8(1), pp. 9 - 16
DOI: 10.13189/ijbb.2020.080102
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Nephroprotective Effects of Aqueous Extracts of Hibiscus sabdariffa Calyces and Jatropha curcas Leaves against Lead Toxicity

Okonkwo , Chioma Joy ^*, Belonwu Donatus Chuka , Monago-Ighorodje C. Comfort , Okonkwo Chinedu Joseph , Oforibo , Esther Clement
Department of Biochemistry, University of Port Harcourt, Rivers state, Nigeria

ABSTRACT

Background: Lead is a persistent heavy metal which has been found to be a multi-organ toxicant. In recent times, plants containing natural compounds with both chelating and antioxidant activities are considered as promising candidates for managing lead toxicity. Objectives: The present investigation was undertaken to evaluate the ameliorative potentials of aqueous extracts of Jatropha curcas (JC) leaves and Hibiscus sabdariffa (HS) calyces against renal toxicity resulting from lead acetate exposure. Materials and Methods: Ten groups of male Wistar rats were taken: The first and second groups represented the normal and lead acetate (PbA) (50mg/kg b.w) control groups respectively while groups 3 and 4 were given 100mg/kg JC and 200 mg/kg JC respectively. Groups 5 and 6 received 250 mg/kg HS and 500 mg/kg HS respectively. Groups 7-10 were given PbA (50mg/kg) and 100mg/kg JC, 200 mg/kg JC, 250mg/kg HS, 500mg/kg HS respectively. Rats were orally administered their relevant doses for 28 days. Blood samples were collected from heart puncture at the end of the experiment (28 days) for renal function analysis. Result: Serum creatinine and urea concentrations were significantly higher (p < 0.05) in the lead acetate group compared to the normal control. The renal morphology of the lead-exposed rats also revealed the degeneration and necrosis in tubules and swelling in the glomerulus. The significant increase in renal markers and morphological alterations after lead toxicity induction were moderately normalized by the administration of aqueous extracts of Jatropha curcas and Hibiscus sabdariffa. Conclusions: Results demonstrated moderate beneficial effects of J. curcas and H. sabdariffa treatment in managing Pb-induced tissue damage in the kidney.

KEYWORDS
Lead Toxicity, Nephroprotection, Jatropha curcas, Hibiscus sabdariffa

Cite This Paper in IEEE or APA Citation Styles
(a). IEEE Format:
[1] Okonkwo , Chioma Joy , Belonwu Donatus Chuka , Monago-Ighorodje C. Comfort , Okonkwo Chinedu Joseph , Oforibo , Esther Clement , "Nephroprotective Effects of Aqueous Extracts of Hibiscus sabdariffa Calyces and Jatropha curcas Leaves against Lead Toxicity," International Journal of Biochemistry and Biophysics, Vol. 8, No. 1, pp. 9 - 16, 2020. DOI: 10.13189/ijbb.2020.080102.

(b). APA Format:
Okonkwo , Chioma Joy , Belonwu Donatus Chuka , Monago-Ighorodje C. Comfort , Okonkwo Chinedu Joseph , Oforibo , Esther Clement (2020). Nephroprotective Effects of Aqueous Extracts of Hibiscus sabdariffa Calyces and Jatropha curcas Leaves against Lead Toxicity. International Journal of Biochemistry and Biophysics, 8(1), 9 - 16. DOI: 10.13189/ijbb.2020.080102.