Universal Journal of Plant Science Vol. 1(4), pp. 113 - 117
DOI: 10.13189/ujps.2013.010401
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Cytotoxic Activities of Extracts of Medicinal Plants of Euphorbiacae Family Studied on Seven Human Cancer Cell lines

Ekta Prakash ^*, D.K.Gupta
Department of Biochemistry, Allahabad University, India

ABSTRACT

Plant extracts of species of the family Euphorbiaceae used by traditional healers for the treatment of ulcers, cancers, tumors, warts and other diseases. were tested in vitro for their potential anti-proliferative activity. The objective of the present study was to evaluate the in-vitro anti- cancer effects of ethanolic extract of three plant species namely Ricinus communis Linn, Euphorbia helioscopia, Jatropha curcas of the family Euphorbiaceae by SRB assay against seven human cancer cell lines. Colon cancer cell line (Colon HT-29, SW-20, SiHa, Colon 502717), Liver cancer cell line (Hep-2), Breast cancer cell line (T-47D), Cervix cancer cell line OVCAR-5, Prostrate cancer cell line (PC-3) and Lungs (AF-49). The SRB assay was done in replicates to test cytotoxic activity of the three above mentioned plants against seven human cancer cell lines. The activity was evaluated at 100 µg/ml concentration of test material. Jatropa curcas showed 47% activity against SiHa. The ethanolic fraction of seed part of Ricinus communis showed 41% activity against Colon 502713 while stem part exhibited maximum activity against SiHa (47%). The ethanolic extract of Euphorbia helioscopia inhibited the growth of three cancer cell lines viz Hep-2, T-47D and PC-5.Hep-2 showed 27% activity.

KEYWORDS
Euphorbiaceae, Ricinus Communis, Jatropha, E.Helioscopia, Cytotoxic Activity

Cite This Paper in IEEE or APA Citation Styles
(a). IEEE Format:
[1] Ekta Prakash , D.K.Gupta , "Cytotoxic Activities of Extracts of Medicinal Plants of Euphorbiacae Family Studied on Seven Human Cancer Cell lines," Universal Journal of Plant Science, Vol. 1, No. 4, pp. 113 - 117, 2013. DOI: 10.13189/ujps.2013.010401.

(b). APA Format:
Ekta Prakash , D.K.Gupta (2013). Cytotoxic Activities of Extracts of Medicinal Plants of Euphorbiacae Family Studied on Seven Human Cancer Cell lines. Universal Journal of Plant Science, 1(4), 113 - 117. DOI: 10.13189/ujps.2013.010401.