Universal Journal of Public Health Vol. 7(1), pp. 30 - 35
DOI: 10.13189/ujph.2019.070104
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Non-functioning Pancreatic Neuroendocrine Tumor in a Patient with Multiple Endocrine Neoplasia Type 1 Syndrome: Case Report

Gabriel Brito Barbosa ^1,*, Lucas Santos Pimentel ¹, Arthur Ribeiro Costa Carvalho ², Thais Ribeiro Costa Carvalho ³, Ana Rita Marinho Ribeiro Carvalho ^4
1 Centro Universitário Maurício de Nassau (UNINASSAU), Brazil
² Faculdade de Medicina de Olinda (FMO), Brazil
³ Faculdade Pernambucana de Saúde (FPS), Brazil
⁴ Brazilian College of Radiologists, Brazil

ABSTRACT

Background: Neuroendocrine tumors are rare, but when coexisting with Multiple Endocrine Neoplasia Type 1 Syndrome in the same patient, the literature shows 80 to 100% association. Represents an autosomal dominant disorder due to mutations in tumor suppressor gene MEN1 and it's defined as the development of two or more tumors from the main three endocrine sites: the parathyroid glands, the pancreatic islet and the Pituitary gland. We present a case of a patient with a compatible family history and classic imaging findings for MEN1 Syndrome. Case report: Male, 28 years old patient genetically diagnosed with the MEN 1 Syndrome who presented to our image service for abdominal tumors' screening. Submitted through multiples imaging exams such as CT, MRI, PET/CT to follow up the diagnosis, in which was found a pancreatic mass measuring over 3 cm, with another 3 little pancreatic lesions as well. The patient received indication to surgery, with further anatomopathological and immunohistochemistry studies confirming the well- differentiated neuroendocrine tumor. Conclusion: Due to the wide range of malignant potential, it's recommended annual screening, as minimum, with biochemical and image techniques. Surgery is the only treatment capable of tumor's eradication, which consists on a pancreatectomy (lesions sized more than 1-2 cm).

KEYWORDS
Multiple Endocrine Neoplasia Type 1, Neuroendocrine Tumors, Radiology, Computerized Tomography, Magnetic Resonance Image, Endoscopic Ultrasound

Cite This Paper in IEEE or APA Citation Styles
(a). IEEE Format:
[1] Gabriel Brito Barbosa , Lucas Santos Pimentel , Arthur Ribeiro Costa Carvalho , Thais Ribeiro Costa Carvalho , Ana Rita Marinho Ribeiro Carvalho , "Non-functioning Pancreatic Neuroendocrine Tumor in a Patient with Multiple Endocrine Neoplasia Type 1 Syndrome: Case Report," Universal Journal of Public Health, Vol. 7, No. 1, pp. 30 - 35, 2019. DOI: 10.13189/ujph.2019.070104.

(b). APA Format:
Gabriel Brito Barbosa , Lucas Santos Pimentel , Arthur Ribeiro Costa Carvalho , Thais Ribeiro Costa Carvalho , Ana Rita Marinho Ribeiro Carvalho (2019). Non-functioning Pancreatic Neuroendocrine Tumor in a Patient with Multiple Endocrine Neoplasia Type 1 Syndrome: Case Report. Universal Journal of Public Health, 7(1), 30 - 35. DOI: 10.13189/ujph.2019.070104.