International Journal of Biochemistry and Biophysics Vol. 6(2), pp. 37 - 43
DOI: 10.13189/ijbb.2018.060202
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Tramadol Encapsulation in Aqueous Phase of Water/Oil Pickering Emulsion Stabilized by Magnesium Oxide Particles

Papa Mady SY ^1,*, Sidy Mouhamed Dieng ¹, Louis Augustin Diaga Diouf ¹, Alphonse Rodrigue Djiboune ¹, Mamadou Soumboundou ¹, Boucar Ndong ², Ousseynou Diop ², El Hadji Amadou Lamine Bathily ², Gora Mbaye, Marthe Diouf ¹, Mamadou Mbodj ², Mounibé Diarra ^1
1 Laboratory of Physics and Pharmaceutical Biophysics, Faculty of Medicine, Pharmacy and Odontology, Cheikh Anta Diop University (UCAD), Dakar, Senegal
² Laboratory of Medical Biophysics and Nuclear Medicine, Faculty of Medicine, Pharmacy and Odontology, Cheikh Anta Diop University (UCAD), Dakar, Senegal

ABSTRACT

Pickering emulsions are systems without surfactants, stabilized by solid particles. These emulsions are experiencing a renewed interest, on the one hand, because it is preferable to limit the use of synthetic surfactants for toxicological and environmental reasons and, on the other hand, the need to make new formulations in order to control the drug release patterns by encapsulation or controlled release. Thus, we were interested in the formulation and evaluation of W / O Pickering emulsions stabilized by particles of magnesium oxide with tramadol hydrochloride in the internal phase. The Bancroft rule served as a model for the formulation. The emulsification was carried out by progressively adding an aqueous phase dispersed in an oil-dispersing phase using a turbo rotor stator mixer. The stability of these emulsions was studied using several parameters (droplet size, pH, viscosity, conductivity...) and the qualitative and quantitative analysis of the active ingredient by UV-visible spectrophotometry. The results obtained showed that the dye test and the conductivity measurement confirmed the W / O nature of these emulsions. Some parameters such as droplet size, pH and viscosity were strongly influenced by the amounts of Magnesium oxide particles and the active ingredient. The qualitative and quantitative analysis of the active ingredient confirmed the presence of tramadol in the internal aqueous phase. Thus, we have succeeded in developing a stable W / O Pickering emulsion with magnesium oxide particles. In addition, we were able to encapsulate tramadol in the dispersed aqueous phase.

KEYWORDS
Emulsion, Pickering, MgO, Tramadol Hydrochloride

Cite This Paper in IEEE or APA Citation Styles
(a). IEEE Format:
[1] Papa Mady SY , Sidy Mouhamed Dieng , Louis Augustin Diaga Diouf , Alphonse Rodrigue Djiboune , Mamadou Soumboundou , Boucar Ndong , Ousseynou Diop , El Hadji Amadou Lamine Bathily , Gora Mbaye, Marthe Diouf , Mamadou Mbodj , Mounibé Diarra , "Tramadol Encapsulation in Aqueous Phase of Water/Oil Pickering Emulsion Stabilized by Magnesium Oxide Particles," International Journal of Biochemistry and Biophysics, Vol. 6, No. 2, pp. 37 - 43, 2018. DOI: 10.13189/ijbb.2018.060202.

(b). APA Format:
Papa Mady SY , Sidy Mouhamed Dieng , Louis Augustin Diaga Diouf , Alphonse Rodrigue Djiboune , Mamadou Soumboundou , Boucar Ndong , Ousseynou Diop , El Hadji Amadou Lamine Bathily , Gora Mbaye, Marthe Diouf , Mamadou Mbodj , Mounibé Diarra (2018). Tramadol Encapsulation in Aqueous Phase of Water/Oil Pickering Emulsion Stabilized by Magnesium Oxide Particles. International Journal of Biochemistry and Biophysics, 6(2), 37 - 43. DOI: 10.13189/ijbb.2018.060202.