Universal Journal of Public Health Vol. 6(2), pp. 56 - 62
DOI: 10.13189/ujph.2018.060204
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An Open-label Randomized Clinical Study to Compare the Effects of a Nutritional Supplement versus Vitamin E on Fibroscan Score in Nonalcoholic Steatohepatitis (NASH) Patients

Shahed Ashraf ^1,*, Jamshed Alam ¹, Jahangir Alam Sarkar ¹, Faiz Ahmed Khondaker ¹, Yusuf Farhana ², Naila Atik Khan ^3
1 Department of Hepatology, Shaheed Suhrawardy Medical College Hospital, Sher- E- Bangla Nagar, Bangladesh
² Department of Pathology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
³ Department of Biochemistry & Molecular Biology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh

ABSTRACT

Background: Despite the benefit of lifestyle changes, there is no standard treatment for Fibrotic NASH. However the concept of reversibility of liver fibrosis and cirrhosis with various natural biologically active compounds and antioxidant micro-nutrients is not new. Aim: The aim of this study was to compare effectiveness of Viusid^® (a nutritional supplement) and Vitamin E in reducing steatosis and liver fibrosis score in patients with fibrotic NASH. Methods: 52 patients diagnosed with nondiabetic and noncirrhotic NASH on liver fibroscan were divided into 2 groups randomly and given Viusid^® 3 sachets daily to 25 patients or Vitamin E 800 IU daily to 27 patients along with a hypocaloric diet and exercise for 3 months. Results: After 3 months treatment with Viusid^®, as compared with Vitamin E, was associated with a significant reduction of both mean steatosis score (CAP value reduces from 286±16.3 to 208±18.5 dB/m in Viusid^® group vs. from 278±14.4 to 253±12.1 dB/m in Vitamin E group; p<0.00001) and fibrosis score (E value reduces from 6.8±0.5 to 5.1±0.7 kPa in Viusid^® group vs. from 6.9±0.5 to 6.5±0.4 kPa in Vitamin E group; p<0.00001). Similarly, the mean alanine transaminase (ALT) levels also significantly decreased from 114±25.9 U/L to 43±9.1 U/L in Viusid^® group compared to from 105±15.5 U/L to 55±11.7 U/L in vitamin E group (p>0.00001). Conclusions: Viusid^® was superior to Vitamin E in reducing steatosis & fibrosis score in nondiabetic and noncirrhotic NASH patients. However, further large scale trial is needed to better assess the value of Viusid^® for fibrotic NASH management.

KEYWORDS
Steatosis, Nonalcoholic Steatohepatitis, Fibrosis, Antioxidant Micro-nutrients, Viusid^®, Vitamin E

Cite This Paper in IEEE or APA Citation Styles
(a). IEEE Format:
[1] Shahed Ashraf , Jamshed Alam , Jahangir Alam Sarkar , Faiz Ahmed Khondaker , Yusuf Farhana , Naila Atik Khan , "An Open-label Randomized Clinical Study to Compare the Effects of a Nutritional Supplement versus Vitamin E on Fibroscan Score in Nonalcoholic Steatohepatitis (NASH) Patients," Universal Journal of Public Health, Vol. 6, No. 2, pp. 56 - 62, 2018. DOI: 10.13189/ujph.2018.060204.

(b). APA Format:
Shahed Ashraf , Jamshed Alam , Jahangir Alam Sarkar , Faiz Ahmed Khondaker , Yusuf Farhana , Naila Atik Khan (2018). An Open-label Randomized Clinical Study to Compare the Effects of a Nutritional Supplement versus Vitamin E on Fibroscan Score in Nonalcoholic Steatohepatitis (NASH) Patients. Universal Journal of Public Health, 6(2), 56 - 62. DOI: 10.13189/ujph.2018.060204.