Journals Information
Universal Journal of Public Health Vol. 5(7), pp. 371 - 381
DOI: 10.13189/ujph.2017.050705
Reprint (PDF) (416Kb)
CD4 Recovery and Survival among Adults Co-infected with HIV and Hepatitis B or C Virus, Ho Chi Minh City, Vietnam
Hao Duong 1,2,*, Son Nguyen 2, Ray Shiraishi 3, Hung Trinh 4, Hanh Vo 5, Thu-Van Tieu 4, Hung Van 4, Thinh Tran 4, Marta Ackers 1, Siobhán O'Connor 6
1 U.S. Centers for Disease Control and Prevention, Division of Global HIV and TB, Hanoi, Vietnam
2 The Partnership for Health Advancement in Vietnam (HAIVN), HCMC, Vietnam
3 U.S. Centers for Disease Control and Prevention, Division of Global HIV and TB, Atlanta, GA, USA
4 The Provincial AIDS Committee (PAC), Ho Chi Minh City (HCMC), Vietnam
5 Pham Ngoc Thach University of Medicine, Ho Chi Minh City (HCMC), Vietnam
6 U. S. Centers for Disease Control and Prevention, Division of Viral Hepatitis, Atlanta, GA, USA
ABSTRACT
This study assessed associations between hepatitis B and C virus (HBV, HCV) and increases in CD4 count and survival among 4316 HIV-infected patients on non-tenofovir (TDF)-based antiretroviral treatment (ART) in Ho Chi Minh City, Vietnam during 2006-2010, using mixed-effects model and survival analysis. More than half of patients (52.4%) participating in the study were HBsAg-negative/anti-HCV-negative, 9.0% HBsAg positive/anti-HCV-negative, and 38.6% anti-HCV-positive. Anti-HCV-positive males had smaller increases in CD4 count during the first two years of ART, but larger increases between two and three years after ART initiation than anti-HCV-negative females (regardless of HBsAg status) and HBsAg-negative/anti-HCV-negative males. Magnitude of the differences was small. Overall mortality rate was 15 per 1000 person-years; HBsAg and anti-HCV status were not significantly associated with mortality. Co-infection with HBV (HBsAg-positive) and/or exposure to HCV (anti-HCV-positive) does not seem to have substantial effects on outcomes of patients on non-TDF-containing ART during a median follow-up of 1.72 years. It may take a longer time for assessing effects of co-infection with HBV and/or HCV on ART outcomes. Such assessments should focus on those with positive HCV RNA, instead of positive anti-HCV.
KEYWORDS
HIV, Hepatitis B Virus, Hepatitis C Virus, ART, CD4, Mortality, Survival
Cite This Paper in IEEE or APA Citation Styles
(a). IEEE Format:
[1] Hao Duong , Son Nguyen , Ray Shiraishi , Hung Trinh , Hanh Vo , Thu-Van Tieu , Hung Van , Thinh Tran , Marta Ackers , Siobhán O'Connor , "CD4 Recovery and Survival among Adults Co-infected with HIV and Hepatitis B or C Virus, Ho Chi Minh City, Vietnam," Universal Journal of Public Health, Vol. 5, No. 7, pp. 371 - 381, 2017. DOI: 10.13189/ujph.2017.050705.
(b). APA Format:
Hao Duong , Son Nguyen , Ray Shiraishi , Hung Trinh , Hanh Vo , Thu-Van Tieu , Hung Van , Thinh Tran , Marta Ackers , Siobhán O'Connor (2017). CD4 Recovery and Survival among Adults Co-infected with HIV and Hepatitis B or C Virus, Ho Chi Minh City, Vietnam. Universal Journal of Public Health, 5(7), 371 - 381. DOI: 10.13189/ujph.2017.050705.