Advances in Pharmacology and Pharmacy Vol. 1(3), pp. 139 - 143
DOI: 10.13189/app.2013.010304
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Formulation and Development of Diltiazem Hydrochloride Sustained Release Alginate Beads by Ionotropic External Gelation Technique

Mokale Vinod ^*, Naik Jitendra , Khairnar Gayatri , Khairnar Gokul
Department of Pharmaceutical Technology, University Institute of Chemical Technology, North Maharashtra University, Jalgaon, 425 001, Maharashtra

ABSTRACT

Background of the research: Diltiazem HCL (DTZ), has short biological half life of 3-4 h, requires rather high frequency of administration.Due to repeated administration there may be a chances of patient incompliance and toxicity problems. Objective: The objective of study was to develop sustained release alginate beads of DTZ for reduction in dosing frequency, high bioavailability & better patient compliance. Methodology: Alginate beads were prepared by ionotropic external gelation technique using CaCl₂ as cross linking agent. Prepared beads were evaluated for % yield, encapsulation efficiency, swelling index in 0.1N HCL and 7.4 phosphate buffer, drug release study, FT-IR, FE-SEM analysis. In order to improve %EE and drug release, pectin, methyl cellulose and locust bean gum were used as co-polymers along with sodium alginate. Result: Yield was found to be in the range of 72.41-96.43. % EE was 47.3% (F1), 71.1% (F5). In pH 7.4, beads showed increase in swelling index as compare to in 0.1 N HCL. Among use of different copolymers, locust bean gum sustained the DTZ release up to 55.98% (F6) in 12 hrs. FT-IR analysis revealed no drug excipient interference. Prepared beads were found to be rough, with cracks and pores on the surface. Conclusion: It was concluded that DTZ could be successfully entrapped and sustained in sodium alginate beads with use of locust bean gum.

KEYWORDS
Alginate Beads, Diltiazem Hydrochloride, Ionotropic Gelation, Swelling Index

Cite This Paper in IEEE or APA Citation Styles
(a). IEEE Format:
[1] Mokale Vinod , Naik Jitendra , Khairnar Gayatri , Khairnar Gokul , "Formulation and Development of Diltiazem Hydrochloride Sustained Release Alginate Beads by Ionotropic External Gelation Technique," Advances in Pharmacology and Pharmacy, Vol. 1, No. 3, pp. 139 - 143, 2013. DOI: 10.13189/app.2013.010304.

(b). APA Format:
Mokale Vinod , Naik Jitendra , Khairnar Gayatri , Khairnar Gokul (2013). Formulation and Development of Diltiazem Hydrochloride Sustained Release Alginate Beads by Ionotropic External Gelation Technique. Advances in Pharmacology and Pharmacy, 1(3), 139 - 143. DOI: 10.13189/app.2013.010304.