Advances in Diabetes and Metabolism Vol. 5(4), pp. 59 - 64
DOI: 10.13189/adm.2017.050402
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Effects of Aqueous and Ethanolic Extracts of Roasted and Ground Coffee Beans of Coffea canephora robusta on Glycemia and Release and Storage of Hepatic Glucose in Normoglycemic and Diabetic Rats


Aka F. B. Angelo 1, Kablan A. L.Claude 2,*, Kati-Coulibaly Séraphin 1
1 Felix Houphouet Boigny University, Ivory Coast, Côte d'Ivoire
2 Peleforo Gon Coulibaly University of Korhogo, Ivory Coast, Côte d'Ivoire

ABSTRACT

The drink from the roasted and ground coffee beans of Coffea, which has been blamed, with alcohol, tobacco and drugs have been recognized for over a decade as a drink with positive effects on health. Among its benefits is an inverse association between low coffee consumption and high prevalence of type 2 diabetes. This study aims at evaluating the antidiabetic effects of an aqueous extract of roasted and ground beans of Coffea canephora robusta associated with a sulphonylurea (Glibenclamide) on glycaemia and on the release and storage of hepatic glucose among rats made diabetic by alloxan. Simultaneous oral administration of 20 mg/kg bw of aqueous extract of roasted and ground coffee beans of coffea canephora robusta + 10 mg/kg bw of glibenclamide after 28 days of treatment results in a highly significant decrease in blood glucose in diabetics rats, potentiating the effect of glibenclamide. Compared to aqueous and residual aqueous extracts, the ethanolic extract of roasted and ground beans of Coffea canephora robusta has a better inhibition of the release of hepatic glucose in the normoglycemic rats. After 90 days of treatment, the combination of coffee + glibenclamide favour more the storage of hepatic glucose compared with to diabetic rats treated only with glibenclamide. It appears that the aqueous extract of roasted and ground beans of Coffea canephora robusta would have antidiabetic properties and would act by supporting on the one hand the inhibition of the glycogenolysis and on the other hand the storage of hepatic glucose (glycogenogenesis). These results are quite in favour of the preventive effects from beverage resulting from roasted and ground Coffea in the appearance of type 2 diabetes.

KEYWORDS
Diabetes, Coffea canaphora robusta, Alloxane, Glycaemia, Glycogenogenesis, Glycogenogenesis

Cite This Paper in IEEE or APA Citation Styles
(a). IEEE Format:
[1] Aka F. B. Angelo , Kablan A. L.Claude , Kati-Coulibaly Séraphin , "Effects of Aqueous and Ethanolic Extracts of Roasted and Ground Coffee Beans of Coffea canephora robusta on Glycemia and Release and Storage of Hepatic Glucose in Normoglycemic and Diabetic Rats," Advances in Diabetes and Metabolism, Vol. 5, No. 4, pp. 59 - 64, 2017. DOI: 10.13189/adm.2017.050402.

(b). APA Format:
Aka F. B. Angelo , Kablan A. L.Claude , Kati-Coulibaly Séraphin (2017). Effects of Aqueous and Ethanolic Extracts of Roasted and Ground Coffee Beans of Coffea canephora robusta on Glycemia and Release and Storage of Hepatic Glucose in Normoglycemic and Diabetic Rats. Advances in Diabetes and Metabolism, 5(4), 59 - 64. DOI: 10.13189/adm.2017.050402.