Universal Journal of Plant Science Vol. 5(3), pp. 41 - 44
DOI: 10.13189/ujps.2017.050302
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Antimicrobial, Antifungal & Cytotoxic Activities Screening of Stem Bark Fractions from Terminalia chebula


Md. Lutful Kabir 1, Mohammad Tuhin Ali 2, Md. Enamul Haque 2,*
1 Department of Biochemistry and Molecular Biology, Bangabandhu Sheikh Mujibur Rahman Science & Technology University, Bangladesh
2 Department of Biochemistry and Molecular Biology, University of Dhaka, Bangladesh

ABSTRACT

The fractionated crude extracts and two isolated pure compounds TC-1(Phytol) and TC-2(Stigmasterol) from stem bark of Terminalia chebula were screened for their antibacterial and antifungal activities and cytotoxicity against brine shrimp nauplii. Petroleum ether, ethyl acetate (EtOAc) and methanol (MeOH) extracts and the compounds isolated from EtOAC fractions were studied for their antimicrobial activities. Cytotoxic activities were conducted only with crude extract. Both EtOAc and petroleum ether extract showed promising and moderate antimicrobial activities against most of the gram positive and gram negative bacteria whereas the MeOH extract did not show any antimicrobial activities. The isolated pure compounds TC-1 & TC-2 exhibited activities against most of the bacterial strains. The cytotoxicity towards brine shrimp nauplii of the crude extract was studied. The LC50 values of plant crude extract is found to be 5.623413µg/mL.

KEYWORDS
Antimicrobial, Cytotoxic. Terminalia chebula

Cite This Paper in IEEE or APA Citation Styles
(a). IEEE Format:
[1] Md. Lutful Kabir , Mohammad Tuhin Ali , Md. Enamul Haque , "Antimicrobial, Antifungal & Cytotoxic Activities Screening of Stem Bark Fractions from Terminalia chebula," Universal Journal of Plant Science, Vol. 5, No. 3, pp. 41 - 44, 2017. DOI: 10.13189/ujps.2017.050302.

(b). APA Format:
Md. Lutful Kabir , Mohammad Tuhin Ali , Md. Enamul Haque (2017). Antimicrobial, Antifungal & Cytotoxic Activities Screening of Stem Bark Fractions from Terminalia chebula. Universal Journal of Plant Science, 5(3), 41 - 44. DOI: 10.13189/ujps.2017.050302.