Advances in Diabetes and Metabolism Vol. 5(1), pp. 12 - 19
DOI: 10.13189/adm.2017.050103
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Evaluation of Antidiabetic Activity of Aqueous and Etylic alcohol Extracts of Stem Bark of Xylopia villosa Chipp (Annonaceae)

Kouame Yao Yves ^1,*, Okpekon Aboua Timothée ², Yapi Houphouët Félix ^1
1 Laboratory of Pharmacodynamics Biochemical, UFR Biosciences, Felix Houphouet Boigny University, Cote d'Ivoire
² Laboratory of Organic Chemistry and Natural Substances, UFR Sciences of Structures of Matter and Technology, Felix Houphouet Boigny University, Cote d'Ivoire

ABSTRACT

This study aims to evaluate antidiabetic activity of aqueous and ethanolic extracts of Xylopia villosa stem bark. Induction of diabetes was made with Streptozocin on male rats. Treatments of diabetic rats with aqueous and ethanolic extracts of Xylopia villosa at doses of 100 and 200 mg / kg bw and Daonil (the reference molecule) at doses of 10 and 20 mg / kg bw revealed that ethanolic extract (200 mg / kg) bw behaved like Daonil (20 mg / kg bw). It is the therapeutic dose needed to correct hyperglycaemia. At this dose, the ethanolic extract allowed an important insulin secretion equivalent to the non-diabetic control rats and allowed the gradual reconstitution of the islets of Langerhans and the reappearance of the β cells responsible for the secretion of the insulin. This situation would be linked to the flavonoids and zinc contained in the extracts. Indeed, Zinc, in addition to being a powerful antioxidant, would have a protective insulin action and an important insulin-like effect by activating the kinases involved in insulin signaling and the phosphorylations necessary for insulin efficacy. Also, flavonoids improve the sensitivity of the body's cells to insulin, which reduces the incidence of type 2 diabetes.

KEYWORDS
Xylopia villosa, Streptozocin, Antidiabetic, Glycaemia, Insulin

Cite This Paper in IEEE or APA Citation Styles
(a). IEEE Format:
[1] Kouame Yao Yves , Okpekon Aboua Timothée , Yapi Houphouët Félix , "Evaluation of Antidiabetic Activity of Aqueous and Etylic alcohol Extracts of Stem Bark of Xylopia villosa Chipp (Annonaceae)," Advances in Diabetes and Metabolism, Vol. 5, No. 1, pp. 12 - 19, 2017. DOI: 10.13189/adm.2017.050103.

(b). APA Format:
Kouame Yao Yves , Okpekon Aboua Timothée , Yapi Houphouët Félix (2017). Evaluation of Antidiabetic Activity of Aqueous and Etylic alcohol Extracts of Stem Bark of Xylopia villosa Chipp (Annonaceae). Advances in Diabetes and Metabolism, 5(1), 12 - 19. DOI: 10.13189/adm.2017.050103.