Food Science and Technology Vol. 4(4), pp. 78 - 88
DOI: 10.13189/fst.2016.040405
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In-vitro and in-vivo Consideration of Repaglinide Immediate-release Tablet: Assessment of Porous Aceto-starch as a Promising Carrier for Dissolution Rate Enhancement

Vivekanand K. Chatap ^*, Savita D. Patil
Department of Pharmacology, H. R. Patel Institute of Pharmaceutical Education and Research, India

ABSTRACT

In the present investigation, porous aceto-starch has been prepared for the first time using aqua-gel to an aceto-gel method to facilitate solubility and dissolution rate of Repaglinide (RPGD) to enhance oral bioavailability. The RPGD was selected as a model drug due to its low aqueous solubility and dissolution rate in GI fluid. Fabricated aceto-starch was characterized using FT-IR, DSC, XRPD, BET and FESEM studies followed by in-vitro drug release rate. It showed outstanding features like high surface area, good drug loading and significant improvement in drug dissolution rate, making it a potential drug carrier. Consequently, repaglinide loaded aceto-starch (R-aceto-starch) immediate-release tablets were prepared by direct compression method. Pre and post-compression parameters for blend and tablets were studied and found within pharmacopoeial acceptable limits. R-aceto-starch and immediate-release tablets demonstrated improved dissolution rate compared with pure crystalline RPGD, physical mixture and marketed tablets. The in-vivo assessment of tablet indicated efficient control of blood glucose levels than pure RPGD and showed good in-vitro and in-vivo correlation. The results of stability studies revealed that there were no significant differences in physico–chemical parameters and dissolution rate between the initial and stored R-acetostarch immediate-release tablets. In a nutshell, it can be concluded that encapsulating poorly soluble drugs in porous aceto-starch would be an innovative strategy for dissolution rate enhancement of BCS II drug, when administered orally.

KEYWORDS
Repaglinide, Aceto-starch, Sol-gel Method, Immediate-release Tablet, Dissolution Rate Enhancement, In-Vitro and in-Vivo Correlation

Cite This Paper in IEEE or APA Citation Styles
(a). IEEE Format:
[1] Vivekanand K. Chatap , Savita D. Patil , "In-vitro and in-vivo Consideration of Repaglinide Immediate-release Tablet: Assessment of Porous Aceto-starch as a Promising Carrier for Dissolution Rate Enhancement," Food Science and Technology, Vol. 4, No. 4, pp. 78 - 88, 2016. DOI: 10.13189/fst.2016.040405.

(b). APA Format:
Vivekanand K. Chatap , Savita D. Patil (2016). In-vitro and in-vivo Consideration of Repaglinide Immediate-release Tablet: Assessment of Porous Aceto-starch as a Promising Carrier for Dissolution Rate Enhancement. Food Science and Technology, 4(4), 78 - 88. DOI: 10.13189/fst.2016.040405.