Advances in Diabetes and Metabolism(CEASE PUBLICATION) Vol. 4(4), pp. 65 - 72
DOI: 10.13189/adm.2016.040402
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Estimated Glomerular Filtration Rate and Associated Clinical and Biochemical Characteristics in Type 2 Diabetes Patients

Abha Pandit ^1,*, Abhay Kumar Pandey ^2
1 Department of Medicine, Index Medical College Indore, India
² Department of Physiology, Government Medical College Banda, India

ABSTRACT

Background: Improved check on cardiovascular mortality due to diabetes has fast increased life span and prevalence of nephropathy in diabetics world over. Its variegated insidious sequel requiring useful markers for timely detection and address. Professional dictat is for periodic monitoring of estimated glomerular filtration rate (eGFR) in the diabetes patients. An indication of nephropathy from overall routine clinical and laboratory findings is worthwhile too. Objective: Study of clinico-demographic and biochemical indices associated with diabetic nephropathy defined by cutoff decline in eGFR, was undertaken to generate local evidence base for practice guidance. Method: 136 patients of type 2 diabetes mellitus under treatment at medicine outdoor for at least past one year were classified by eGFR cutoff of 60ml/min/1.73m² in to renal impaired (chronic kidney disease CKD group) and unimpaired groups. In a cross sectional study their clinico-demographic characteristics and biochemical investigation profiles were analysed and compared to elucidate local clinical evidence on relevant markers of CKD in type 2 diabetes. Result and Conclusion: Central obesity, long standing disease, inadequate glycaemic control, macroproteinuria, lower HDL-cholesterol and lower plasma antioxidant capacity profiles prominently associated diabetic patients with CKD. Hypertension was not prominently associated. Weight reduction, antioxidant nutrient supplements, better glycaemic control and improvement of HDL-cholesterol profiles were apparently demanding greater attention and care toward abetting/retarding occurrence of nephropathy in type 2 diabetes patients.

KEYWORDS
Diabetic Nephropathy, Chronic Kidney Disease, Estimated GFR, Type 2 Diabetes, Diabetic Complications

Cite This Paper in IEEE or APA Citation Styles
(a). IEEE Format:
[1] Abha Pandit , Abhay Kumar Pandey , "Estimated Glomerular Filtration Rate and Associated Clinical and Biochemical Characteristics in Type 2 Diabetes Patients," Advances in Diabetes and Metabolism(CEASE PUBLICATION), Vol. 4, No. 4, pp. 65 - 72, 2016. DOI: 10.13189/adm.2016.040402.

(b). APA Format:
Abha Pandit , Abhay Kumar Pandey (2016). Estimated Glomerular Filtration Rate and Associated Clinical and Biochemical Characteristics in Type 2 Diabetes Patients. Advances in Diabetes and Metabolism(CEASE PUBLICATION), 4(4), 65 - 72. DOI: 10.13189/adm.2016.040402.