Universal Journal of Public Health Vol. 4(5), pp. 239 - 243
DOI: 10.13189/ujph.2016.040503
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Comparison of Radiological Criteria (RECIST - MASS - SACT -Choi) in Antiangiogenic Therapy of Renal Cell Carcinoma

Vancini C. ^1,*, De Falco Alfano D. ², Abousiam R.N. ², Totaro M. ², Murri Dello Diago N. ³, Giganti M. ^2
1 Department of Radiology, AUSL Romagna, Bufalini Hospital, Italy
² Department of Morphology, Surgery and Experimental Medicine, Diagnostic Imaging Section, University of Ferrara, Italy
³ Department of Radiology, SS. Annunziata Hospital, Italy

ABSTRACT

Aim: To compare the diagnostic accuracy of different radiological criteria used in the assessments of antiangiogenic response in patients with metastatic Renal Cell Carcinoma (RCC). Methods: 44 patients were retrospectively evaluated from January 2007 through September 2014, the patients had histologic diagnosis of RCC, existence of target lesions, in therapy with Sorafenib or Sunitinib assumed continuously for 4 weeks for a total of 6 cycles and went through multiphase CT before and 3 months after the therapy. Results: Out of the 44 patients, 21 had Progression Free Survival (PFS) > 250 days. In this group of patients, all the radiological criteria had high predictive value with slightly higher sensitivity for the RECIST 1.1 criteria (sensitivity 100%). In the remaining group of 23 patients (with PFS < 250 days), RECIST criteria also showed slightly higher specificity values by identifying 9 patients (60.86%) compared with Choi, MASS and SACT who identified respectively 56.52%, 52.17% and 56.52% of the patients as having stable disease or indeterminate response to the therapy. Conclusion: All studied radiological criteria had high predictive value with slightly higher sensitivity results for the RECIST 1.1 criteria.

KEYWORDS
Renal Cell Carcinoma, Assessments of Antiangiogenic Response, Radiological Criteria, RECIST - MASS - SACT - Choi

Cite This Paper in IEEE or APA Citation Styles
(a). IEEE Format:
[1] Vancini C. , De Falco Alfano D. , Abousiam R.N. , Totaro M. , Murri Dello Diago N. , Giganti M. , "Comparison of Radiological Criteria (RECIST - MASS - SACT -Choi) in Antiangiogenic Therapy of Renal Cell Carcinoma," Universal Journal of Public Health, Vol. 4, No. 5, pp. 239 - 243, 2016. DOI: 10.13189/ujph.2016.040503.

(b). APA Format:
Vancini C. , De Falco Alfano D. , Abousiam R.N. , Totaro M. , Murri Dello Diago N. , Giganti M. (2016). Comparison of Radiological Criteria (RECIST - MASS - SACT -Choi) in Antiangiogenic Therapy of Renal Cell Carcinoma. Universal Journal of Public Health, 4(5), 239 - 243. DOI: 10.13189/ujph.2016.040503.