Advances in Diabetes and Metabolism(CEASE PUBLICATION) Vol. 4(3), pp. 45 - 48
DOI: 10.13189/adm.2016.040301
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The Effect of Butyric Acid on GLUT4 and IRS1 Expression in Human Preadipocytes in vitro


L. R. Maness *
Department of Clinical Laboratory Science, Winston-Salem State University, USA

ABSTRACT

Understanding the dietary components that can prevent and treat diabetes mellitus types 2 (DMT2) is important to millions of people who are at risk for and currently suffer from the various aspects of this disease. Our diets can affect our health at the level of gene expression, thus, determining foods that can positively affect cellular activity can be advantageous to our daily lives. Butyric acid is a fatty acid that can be fermented from fiber by beneficial intestinal bacteria. This substance has been shown to improve insulin sensitivity and metabolic activity in mice and to affect genes involved in the insulin pathway both in cell culture and in mice. This study determined the effect of butyric acid on the expression of two genes important to insulin sensitivity, glucose transporter 4 (GLUT4) and insulin receptor substrate 1 (IRS1), in human preadipocytes in vitro. Butyric acid at concentrations 0.05 mg/ml, 0.1 mg/ml, and 1.0 mg/ml each increased the expression of both of these genes, indicating that cells are more sensitive to insulin in the presence of this component. This study indicates that butyric acid can be implemented into dietary plans to prevent and control DMT2 by increasing daily fiber intake.

KEYWORDS
GLUT4, IRS1, Diabetes Mellitus Type 2, Butyric Acid, Preadipocytes

Cite This Paper in IEEE or APA Citation Styles
(a). IEEE Format:
[1] L. R. Maness , "The Effect of Butyric Acid on GLUT4 and IRS1 Expression in Human Preadipocytes in vitro," Advances in Diabetes and Metabolism(CEASE PUBLICATION), Vol. 4, No. 3, pp. 45 - 48, 2016. DOI: 10.13189/adm.2016.040301.

(b). APA Format:
L. R. Maness (2016). The Effect of Butyric Acid on GLUT4 and IRS1 Expression in Human Preadipocytes in vitro. Advances in Diabetes and Metabolism(CEASE PUBLICATION), 4(3), 45 - 48. DOI: 10.13189/adm.2016.040301.