International Journal of Biochemistry and Biophysics Vol. 3(2), pp. 7 - 12
DOI: 10.13189/ijbb.2015.030201
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Importance of Screening Type-II Diabetics for Thyroid Dysfunction and Dyslipidemia

Peeyush Yadav ^1,*, G. G. Kaushik ¹, Sonali Sharma ^2
1 Department of Biochemistry, J.L.N Medical College, India
² Department of Biochemistry, R.U.H.S Medical College, India

ABSTRACT

OBJECTIVE: We aimed to evaluate association between thyroid dysfunction, lipid profile and glycated hemoglobin in type 2 diabetic patients. MATERIALS AND METHODS: The present study has been conducted on 100 diagnosed patients of Diabetes Mellitus Type – II and 100 healthy subjects of either sex of similar age group admitted or attending outpatient department of Jawahar Lal Nehru Hospital, Ajmer. Venous blood sample were withdrawn and assayed for thyroid function such as FT₄, FT₃, T₃, T₄, TSH and other biochemical investigation such as FPG, HbA_1c and lipid profile. Statistical analysis was carried out using the Statistical Package for Social Sciences (SPSS 12.0 for windows). Independent t test was used to compare quantitative data in groups. RESULTS: There is a marked Dyslipidemia with characteristic increase in the levels of Total Cholesterol, TG, VLDL-C, and LDL-C whereas the level of HDL-C decreases in Diabetic patients. Out of 100 Diabetic patients 34 have Thyroid Dysfunction out of which 26 have Hypothyroidism and 8 have Hyperthyroidism. The increase in the value of Serum Total Cholesterol, Triglyceride, LDL-C, VLDL-C and decrease in HDL –C level was observed statistically Highly Significant (p<0.0001) in Hypothyroid Diabetic subjects and Non – Significant (p=0.1072) in Hyperthyroid Diabetic subjects when compared with Euthyroid Diabetic subjects. CONCLUSION: Our study indicates that screening of thyroid dysfunction in type 2 diabetic patients is necessary because in Type 2 diabetics the prevalence of Hypothyroidism was higher with a significant increase in the levels of Total Cholesterol, Triglyceride and LDL - C while the levels of HDL – C decreases.

KEYWORDS
Type 2 Diabetes Mellitus, Thyroid Dysfunction, Dyslipidemia

Cite This Paper in IEEE or APA Citation Styles
(a). IEEE Format:
[1] Peeyush Yadav , G. G. Kaushik , Sonali Sharma , "Importance of Screening Type-II Diabetics for Thyroid Dysfunction and Dyslipidemia," International Journal of Biochemistry and Biophysics, Vol. 3, No. 2, pp. 7 - 12, 2015. DOI: 10.13189/ijbb.2015.030201.

(b). APA Format:
Peeyush Yadav , G. G. Kaushik , Sonali Sharma (2015). Importance of Screening Type-II Diabetics for Thyroid Dysfunction and Dyslipidemia. International Journal of Biochemistry and Biophysics, 3(2), 7 - 12. DOI: 10.13189/ijbb.2015.030201.