Advances in Diabetes and Metabolism Vol. 3(1), pp. 1 - 6
DOI: 10.13189/adm.2015.030101
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Evaluation of Antioxidant Status in Myocardial Infarction in Diabetic and Non-diabetic Subjects: A Comparative Study


K. N Subhakumari *, Reshmy G S , Sajitha Krishnan. P
Department of Biochemistry, Amrita Institute of Medical Sciences, School of Medicine, India

ABSTRACT

Cellular oxidative stress is the leading cause of the worst outcome of myocardial infarction (MI) in diabetes. Diabetes Mellitus is one of the important risk factors for heart pathology, because of increased production of Reactive oxygen Species(ROS).The present study was designed to find out the antioxidant status in diabetic and non-diabetic MI Patients.100 MI patients were grouped into 50 Diabetic MI(group 2) and 50 Non diabetic MI(group 3) and was compared with age matched 50 controls (group1). Malondialdehyde(MDA) or Thiobarbituric acid reactive substances (TBARs), antioxidant enzymes Superoxide Dismutase(SOD) &Catalase were measured in erythrocytes and Vitamin C in plasma was measured. The result showed that there is a significant decrease in the antioxidant status in diabetic and non-diabetic MI patients and a simultaneous significant increase in the lipid peroxidation .Thus there is an imbalance between oxidant and antioxidant molecules in MI patients, and magnitude of imbalance is greater in diabetic MI patients, possibly because of greater oxidative stress in diabetic patients. Potentially antioxidant therapy may play a critical role in reducing morbidity and mortality in MI.

KEYWORDS
Myocardial Infarction, Antioxidants, SOD, Catalase, Vitamin C, TBARs, Oxidative Stress, Reactive Oxygen Species

Cite This Paper in IEEE or APA Citation Styles
(a). IEEE Format:
[1] K. N Subhakumari , Reshmy G S , Sajitha Krishnan. P , "Evaluation of Antioxidant Status in Myocardial Infarction in Diabetic and Non-diabetic Subjects: A Comparative Study," Advances in Diabetes and Metabolism, Vol. 3, No. 1, pp. 1 - 6, 2015. DOI: 10.13189/adm.2015.030101.

(b). APA Format:
K. N Subhakumari , Reshmy G S , Sajitha Krishnan. P (2015). Evaluation of Antioxidant Status in Myocardial Infarction in Diabetic and Non-diabetic Subjects: A Comparative Study. Advances in Diabetes and Metabolism, 3(1), 1 - 6. DOI: 10.13189/adm.2015.030101.