Universal Journal of Chemistry(CEASE PUBLICATION) Vol. 2(3), pp. 30 - 39
DOI: 10.13189/ujc.2014.020301
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Pharmacological Molecule Based on Nanocarbon Container Encapsulated Ferromagnet by Combustion Synthesis for Cancer Therapy

Badis Bendjemil ^1,2,*, Abdelaziz Lankar ³, Djelloul Messadi ¹, Dominique Vrel ^4
1 LASEA, Dept. of Chemistry, University of Badji-Mokhtar, 23000 Annaba, Algeria
² Dept. of Mechanical Engineering, University of 8 Mai 1945 Guelma, 24000 Guelma, Algeria
³ Laboratoire Central d’Anatomie et de Cytologie Pathologiques CHU, 23000 Annaba, Algeria
⁴ LSPM, Université Paris 13, Sorbonne Paris Cité, 99 Av. J. B. Clément, 93430 Villetaneuse, France

ABSTRACT

Combustion synthesis in electrothermal explosion mode can be regarded as an efficient method to obtain new nanomaterials. Different starting mixtures of magnesium powder with various carbonates (Li₂CO₃, Na₂CO₃, CaCO₃, FeCO₃, (NH₄)₂CO₃) were tried and the self-thermal reactions were carried out under both reactive (air) and neutral atmosphere (argon) with an initial pressure of 10 atm to yield novel nanomaterials. Fe, Co, Ni, Pd, Nd, Ta, Ti, Nb, W and NiO powders were used as catalysts and their synthesis and purification have been optimized. Under the applied conditions the presence of crystalline MgO and NaO₂ in products confirmed by XRD analysis, even for the reaction under neutral atmosphere, points to the deep conversion of carbonates. For producing fibrous products the Na₂CO₃ system proved to be the most promising one. FESEM images show the morphology of the products with some 1-D nanostructures resembling carbon nanotubes and nanosized metal/carbon composite (carbon-encapsulated metal-based iron nanoparticles with a core-shell structure with interesting magnetic properties by combustion was obtained. Different magnetic metals (Fe, Ni, and Co) that can be encapsulated by the carbon shell, graphite layers and nanofibers. After purification procedure, we will only obtain core-shell or graphite layers encapsulated by metal magnetic nanoparticles without impurity like noncoated iron or carbides and amorphous carbon. The characterization techniques include the chemical analysis, HRTEM, XRD and FESEM. The obtained novel pharmacological molecular nanostructure will be injected in the cancer tumor cell (prostate) after sterilization. The nanocontainer will be heated by microwave at the Laboratory Central of Anatomie and Cytology Pathology of the CHU Annaba. The reaction will be observed in the HRTEM.

KEYWORDS
1-D Nanostructures, Core-Shell Structure, Graphite Layers, Nano Container Carbon Ferromagnet, Nanofibers

Cite This Paper in IEEE or APA Citation Styles
(a). IEEE Format:
[1] Badis Bendjemil , Abdelaziz Lankar , Djelloul Messadi , Dominique Vrel , "Pharmacological Molecule Based on Nanocarbon Container Encapsulated Ferromagnet by Combustion Synthesis for Cancer Therapy," Universal Journal of Chemistry(CEASE PUBLICATION), Vol. 2, No. 3, pp. 30 - 39, 2014. DOI: 10.13189/ujc.2014.020301.

(b). APA Format:
Badis Bendjemil , Abdelaziz Lankar , Djelloul Messadi , Dominique Vrel (2014). Pharmacological Molecule Based on Nanocarbon Container Encapsulated Ferromagnet by Combustion Synthesis for Cancer Therapy. Universal Journal of Chemistry(CEASE PUBLICATION), 2(3), 30 - 39. DOI: 10.13189/ujc.2014.020301.