Universal Journal of Applied Science Vol. 2(4), pp. 73 - 76
DOI: 10.13189/ujas.2014.020401
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New Lead Molecules from Ascidian Phallusia Nigra (Savigny, 1816) for Type-2 Diabetes Mellitus Targeting Aldose Reductase: An in Silico Approach


G. Ananthan *, A. Selva Prabhu
CAS in Marine Biology, Faculty of Marine Sciences, Annamalai University, Parangipettai-608 502 Tamil Nadu, India

ABSTRACT

Diabetes mellitus is one of the major diseases currently affecting millions of people worldwide. There is a renewed interest in the marine natural products. The present study aimed to identify the bioactive constituents by GC-MS analysis from ascidian P. nigra and screen against type 2 diabetes mellitus protein (aldose reductase) using In-silico approach. Docking studies of the identified compounds were carried out using Arguslab docking software. Analysis of the results indicated Pthalic acid as the potent bioactive constituent attributing Type II Diabetes Mellitus (T2DM) activity from ascidian P. nigra and it showed significant activity than the standard, fidarestat.

KEYWORDS
Docking, Antidiabetic, Arguslab, T2DM, In-Silico, Ascidian, Phallusia Nigra

Cite This Paper in IEEE or APA Citation Styles
(a). IEEE Format:
[1] G. Ananthan , A. Selva Prabhu , "New Lead Molecules from Ascidian Phallusia Nigra (Savigny, 1816) for Type-2 Diabetes Mellitus Targeting Aldose Reductase: An in Silico Approach," Universal Journal of Applied Science, Vol. 2, No. 4, pp. 73 - 76, 2014. DOI: 10.13189/ujas.2014.020401.

(b). APA Format:
G. Ananthan , A. Selva Prabhu (2014). New Lead Molecules from Ascidian Phallusia Nigra (Savigny, 1816) for Type-2 Diabetes Mellitus Targeting Aldose Reductase: An in Silico Approach. Universal Journal of Applied Science, 2(4), 73 - 76. DOI: 10.13189/ujas.2014.020401.