Advances in Pharmacology and Pharmacy Vol. 14(2), pp. 198 - 213
DOI: 10.13189/app.2026.140207
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Dendrimer-Based Nano Carriers for Drug Delivery: Insights into Types, Properties, Interactions, and Biomedical Applications

Gowdru Vishwanath Nahusha , Venkatesh Dinnekere Puttegowda ^*, Joysa Ruby Joseph , Saraisam Kishor Kumar Singha , Ajay Pankajbhai Lunagariya
Department of Pharmaceutics, Acharya & BM Reddy College of Pharmacy, India

ABSTRACT

Dendrimers are intricately branched, nanoscale polymer structures with well-defined architecture, adjustable characteristics, and multiple functional groups, positioning them as advantageous tools for various biomedical uses. This review explores the different classifications of dendrimers, their synthesis techniques, structural attributes, and interaction capabilities for enhanced drug delivery, diagnostics, and therapeutic uses. The distinct features of dendrimers, including their nanoscale dimensions, superb solubility, biocompatibility, and controlled release mechanisms, facilitate substantial progress in targeted treatments, particularly in the realms of cancer therapy, gene delivery, and vaccine development. Recent research indicates that functionalized dendrimers can be utilized for precise drug delivery, which leads to better encapsulation efficiency, increased bioavailability, and lower systemic toxicity. For instance, optimized formulations have demonstrated greater drug loading capacity, improved stability, and pH-responsive release, making them suitable for targeted cancer therapies. Additionally, dendrimers are essential in diagnostics, as they enhance imaging capabilities and the effectiveness of gene therapies. Apart from their biomedical uses, dendrimers have also shown effectiveness in environmental applications, including wastewater treatment and pollutant removal. In summary, dendrimers present a flexible and effective means to address the shortcomings of traditional drug delivery systems. Their ability to provide controlled drug release, customizable designs, and multifunctional capabilities highlights their importance in progressing nanomedicine and various technological advancements. Future studies should aim at improving clinical applications while tackling challenges like toxicity and large-scale manufacturing.

KEYWORDS
Dendrimers, Nanostructure, Targeted Drug Delivery, Carriers, Dendritic, Surface Functional Groups

Cite This Paper in IEEE or APA Citation Styles
(a). IEEE Format:
[1] Gowdru Vishwanath Nahusha , Venkatesh Dinnekere Puttegowda , Joysa Ruby Joseph , Saraisam Kishor Kumar Singha , Ajay Pankajbhai Lunagariya , "Dendrimer-Based Nano Carriers for Drug Delivery: Insights into Types, Properties, Interactions, and Biomedical Applications," Advances in Pharmacology and Pharmacy, Vol. 14, No. 2, pp. 198 - 213, 2026. DOI: 10.13189/app.2026.140207.

(b). APA Format:
Gowdru Vishwanath Nahusha , Venkatesh Dinnekere Puttegowda , Joysa Ruby Joseph , Saraisam Kishor Kumar Singha , Ajay Pankajbhai Lunagariya (2026). Dendrimer-Based Nano Carriers for Drug Delivery: Insights into Types, Properties, Interactions, and Biomedical Applications. Advances in Pharmacology and Pharmacy, 14(2), 198 - 213. DOI: 10.13189/app.2026.140207.