Advances in Pharmacology and Pharmacy Vol. 14(1), pp. 86 - 100
DOI: 10.13189/app.2026.140108
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Revolutionizing Drug Delivery: Future Perspectives, Challenges, Techniques and Applications of Nanosuspension

Ramprasad D. Kadam ¹, Amol S. Rakte ^1,*, Sanjay R. Arote ², Mangesh M. Galbale ^1
1 Department of Pharmaceutics, IVM'S Krishnarao Bhegade Institute of Pharmaceutical Education and Research, Talegaon Dabhade, Tal. Maval, Pune-410507, India
² IVM'S Krishnarao Bhegade Institute of Pharmaceutical Education and Research, Talegaon Dabhade, Tal. Maval Pune-410507, India

ABSTRACT

Nanotechnology is changing how drugs are delivered. It offers new ways to tackle problems with drugs that don't dissolve well in water. This is especially true for certain types of drugs in BCS Classes II & IV. One exciting method in this field is called Nanosuspensions (NS). In this method, drug particles get really tiny down to the nanometer scale. They are mixed into a medium using surfactants to keep them stable. By doing this, we can boost the solubility and the rate of drug dissolution. It also helps the body absorb these drugs better because more surface area is available for interaction. Both targeted distribution and regulated medication release are made possible by NSs! They can be used in many ways: orally, in the eyes, through the lungs, or even through the skin. This review looks at new methods for making NSs. There are techniques like top-down, bottom-up, and even hybrid methods. Some cool approaches include HPH, SF Technology, and Emulsification Solvent Evaporation. Each of these aids in the creation of NSs with special qualities, such as improved stability and particle size distribution. There are problems like long-term stability and large-scale production. Regulatory challenges also make it hard. Researchers aim to overcome these hurdles by using new technologies like microfluidics and personalized medicine. NSs hold promise for solving big challenges in healthcare! By incorporating green chemistry ideas & smart systems to provide long-term answers to pharmaceutical problems, NSs open the door for their wider use in therapeutic settings. This review bridges the gaps between cutting-edge research and real-world applications by offering a thorough grasp of NS technology. It is a useful tool for developing the field of drug delivery, emphasizing how NSs can be used to address important problems such as therapeutic inefficacy, bioavailability variability, and the rising need for effective drug delivery methods.

KEYWORDS
NSs, Poorly Water-Soluble Drugs, Bioavailability Enhancement, High-Pressure Homogenization (HPH), Precipitation Techniques, Nano Edge, Drug Solubility, Particle Size Reduction, Zeta Potential, Pharmaceutical Nanotechnology

Cite This Paper in IEEE or APA Citation Styles
(a). IEEE Format:
[1] Ramprasad D. Kadam , Amol S. Rakte , Sanjay R. Arote , Mangesh M. Galbale , "Revolutionizing Drug Delivery: Future Perspectives, Challenges, Techniques and Applications of Nanosuspension," Advances in Pharmacology and Pharmacy, Vol. 14, No. 1, pp. 86 - 100, 2026. DOI: 10.13189/app.2026.140108.

(b). APA Format:
Ramprasad D. Kadam , Amol S. Rakte , Sanjay R. Arote , Mangesh M. Galbale (2026). Revolutionizing Drug Delivery: Future Perspectives, Challenges, Techniques and Applications of Nanosuspension. Advances in Pharmacology and Pharmacy, 14(1), 86 - 100. DOI: 10.13189/app.2026.140108.