Advances in Pharmacology and Pharmacy Vol. 13(2), pp. 182 - 203
DOI: 10.13189/app.2025.130204
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Validating the Consistency and Quality of "Vaankumari Legiyam": A Classical Siddha Polyherbal Formulation through Advanced Analytical Methods


Sujit Dash 1,*, Minaketan Sahoo 2, Amaresh Chandra Sahoo 3, Mrityunjay Banerjee 4, Prabhat Kumar Sahoo 3, Prabir Kumar Sinha Mahapatra 4, Priyanka Muduli 2
1 Department of Pharmacognosy, Institute of Pharmacy & Technology, Salipur, Cuttack, Odisha-754202, India
2 Department of Pharmaceutical Analysis, Institute of Pharmacy & Technology, Salipur, Cuttack, Odisha-754202, India
3 Department of Pharmaceutics, Institute of Pharmacy & Technology, Salipur, Cuttack, Odisha-754202, India
4 Department of Pharmaceutical Chemistry, Institute of Pharmacy & Technology, Salipur, Cuttack, Odisha-754202, India

ABSTRACT

Among Siddha's internal medicine dosage forms, "Legiyam" stands out as a widely recognized medicinal confectionary. This preparation involves heating decoctions, juices, milk, and sugar to form a syrupy consistency. Drug powders and other ingredients are added, and the mixture is cooled before incorporating butter and honey. "Vaankumaria legiyam," a classic Siddha polyherbal formulation in confectionary form, contains various herbal ingredients known for addressing numerous health concerns, including digestion, diabetes, and skin issues. Commercially available formulations often lack proper standardization, leading to safety and efficacy concerns. In this context, the present study aims to prepare an in-house Siddha formulation using standard raw materials outlined in the Siddha Pharmacopoeia of India. Comparative phytochemical studies were conducted using modern analytical techniques such as AAS, FTIR, HPTLC, and GCMS. The Vaankumari legiyam formulations were tested for heavy metals and trace elements, revealing concentrations below regulatory limits. High-Performance Thin-Layer Chromatography (HPTLC) and Fourier Transform Infrared Spectroscopy (FTIR) analyzed the phytochemical profile, confirming the product's authenticity. Gas Chromatography-Mass Spectrometry (GC-MS) identified and quantified volatile organic compounds, confirming the in-house preparation's reproducibility in capturing aromatic and volatile constituents. These tests confirmed the product's safety for human consumption. The current research has shed light on the potential phytoconstituents responsible for the formulations' claimed therapeutic effects and facilitated quality assessment. The comprehensive analysis of both marketed and in-house formulations of Vaankumari legiyam through various techniques, including phytochemical, physicochemical, AAS, HPTLC, FTIR, and GCMS, has demonstrated consistent equal results.

KEYWORDS
Vaankumari Legiyam, Siddha, Polyherbal Formulation, AAS, FTIR, HPTLC, GCMS

Cite This Paper in IEEE or APA Citation Styles
(a). IEEE Format:
[1] Sujit Dash , Minaketan Sahoo , Amaresh Chandra Sahoo , Mrityunjay Banerjee , Prabhat Kumar Sahoo , Prabir Kumar Sinha Mahapatra , Priyanka Muduli , "Validating the Consistency and Quality of "Vaankumari Legiyam": A Classical Siddha Polyherbal Formulation through Advanced Analytical Methods," Advances in Pharmacology and Pharmacy, Vol. 13, No. 2, pp. 182 - 203, 2025. DOI: 10.13189/app.2025.130204.

(b). APA Format:
Sujit Dash , Minaketan Sahoo , Amaresh Chandra Sahoo , Mrityunjay Banerjee , Prabhat Kumar Sahoo , Prabir Kumar Sinha Mahapatra , Priyanka Muduli (2025). Validating the Consistency and Quality of "Vaankumari Legiyam": A Classical Siddha Polyherbal Formulation through Advanced Analytical Methods. Advances in Pharmacology and Pharmacy, 13(2), 182 - 203. DOI: 10.13189/app.2025.130204.