Advances in Pharmacology and Pharmacy Vol. 13(2), pp. 168 - 181
DOI: 10.13189/app.2025.130203
Reprint (PDF) (1071Kb)


Advancements in Optimizing Microsphere Preparation: A Comprehensive Review of Past Research Utilizing Factorial Design Methodology


Nithyapriya V V , Hindustan Abdul Ahad *, Harshini Krishnan K V , Ashwin C Kotian , Prasenjit Prasad
Department of Pharmaceutics, RR College of Pharmacy, India

ABSTRACT

Microspheres, as versatile carriers for controlled drug delivery, have garnered significant attention in pharmaceutical research because they facilitate drug release kinetics and increase therapeutic efficacy. This abstract presents a comprehensive overview of the preparation of microspheres utilizing factorial design as an optimization strategy. Factorial design, a powerful statistical tool, offers a systematic approach to investigate multiple variables simultaneously, thereby efficiently identifying critical factors influencing the characteristics of microspheres. By systematically varying factors such as polymer type, solvent composition, stirring rate, and drug-to-polymer ratio, factorial design enables the exploration of their individual and interactive effects on microsphere properties. This abstract highlights the key components of factorial design, including the selection of factors and levels, experimental design, data analysis using statistical techniques like analysis of variance (ANOVA), and interpretation of results. Moreover, it elucidates the advantages of factorial design over traditional one-variable-at-a-time methods, such as reduced experimentation time, improved understanding of interactions, and enhanced robustness of the optimization process. Furthermore, this abstract discusses the application of factorial design in optimizing various characteristics of microspheres, containing particle size, morphology, drug entrapment efficiency, and drug discharge profile. By systematically optimizing these parameters, factorial design facilitates the development of microspheres tailored to specific therapeutic requirements, thereby enhancing drug delivery efficacy while minimizing side effects. This abstract underscores the significance of factorial design as a methodical and efficient method for optimizing microspheres in pharmaceutical research.

KEYWORDS
Controlled Drug Delivery, Factorial Design, Microspheres, Optimization, Pharmaceutical Research

Cite This Paper in IEEE or APA Citation Styles
(a). IEEE Format:
[1] Nithyapriya V V , Hindustan Abdul Ahad , Harshini Krishnan K V , Ashwin C Kotian , Prasenjit Prasad , "Advancements in Optimizing Microsphere Preparation: A Comprehensive Review of Past Research Utilizing Factorial Design Methodology," Advances in Pharmacology and Pharmacy, Vol. 13, No. 2, pp. 168 - 181, 2025. DOI: 10.13189/app.2025.130203.

(b). APA Format:
Nithyapriya V V , Hindustan Abdul Ahad , Harshini Krishnan K V , Ashwin C Kotian , Prasenjit Prasad (2025). Advancements in Optimizing Microsphere Preparation: A Comprehensive Review of Past Research Utilizing Factorial Design Methodology. Advances in Pharmacology and Pharmacy, 13(2), 168 - 181. DOI: 10.13189/app.2025.130203.