Advances in Pharmacology and Pharmacy Vol. 13(2), pp. 141 - 159
DOI: 10.13189/app.2025.130201
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Poly(CnO) and Poly(CcO) Organo-Particles Produced from Coconut Oil (CnO) and Cocoa Oil (CcO): Synthesis, Characterization, Bio and Anticancer Activity


Duygu Alpaslan 1,*, Tuba Erşen Dudu 1, Busra Moran Bozer 2, Nahit Aktas 1, Mustafa Turk 3
1 Department of Chemical Engineering, Institute of Natural and Applied Science, Van Yüzüncü Yıl University, Turkey
2 In Vitro Biocompatibility Laboratory, Scientific Technical App. And Research Center, Hitit University, Turkey
3 Department of Bioengineering, Faculty of Engineering, Kirikkale University, Turkey

ABSTRACT

With the increasing number of cancer cases in recent years, the solution methods suggested for these cases are also of great importance. Within the scope of the presented study, we aimed to develop an alternative material in cancer immunotherapy by synthesizing poly(coconut oil) (p(CnO)) and poly(cacao oil) (p(CcO)) organo-particles from coconut and cocoa oils. The structural features of these particles synthesized using the redox polymerization technique were elucidated by various characterization methods. The chemical structure and functional groups of p(CnO) and p(CcO) organo-particles were determined by Fourier Transform Infrared Spectroscopy (FT-IR). Organo particle size and zeta potential values were determined by the dynamic light scattering (DLS) method using Zetasizer device. The morphological features of the particles were determined by Scanning Electron Microscopy (SEM). Bioactivity properties were determined by antioxidant, antimicrobial and biocompatibility analyses. In this study, the effects of p(CnO) and p(CcO) organo-particles on cytotoxicity and apoptotic processes against L-929 fibroblast and Capan-1 pancreatic cancer cell lines were also investigated. p(CnO) and p(CcO) organo-particles Capan-1 cell lines were determined to have significant cytotoxic activity at all doses studied. An increase in cell number was observed in L-929 fibroblast cells treated with p(CnO) and p(CcO) organo-particles. As a result, findings have been obtained that the p(CcO) organo particle triggers the apoptotic mechanism. On Capan-1 pancreatic cancer cells, p(CcO) was found to have a fatal impact akin to that of doxorubicin. It is anticipated that combining p(CcO) with doxorubicin could potentially lead to better outcomes than using doxorubicin alone.

KEYWORDS
Capan-1, Cocco Oil, Coconut Oil, L-929, Organo-Particle

Cite This Paper in IEEE or APA Citation Styles
(a). IEEE Format:
[1] Duygu Alpaslan , Tuba Erşen Dudu , Busra Moran Bozer , Nahit Aktas , Mustafa Turk , "Poly(CnO) and Poly(CcO) Organo-Particles Produced from Coconut Oil (CnO) and Cocoa Oil (CcO): Synthesis, Characterization, Bio and Anticancer Activity," Advances in Pharmacology and Pharmacy, Vol. 13, No. 2, pp. 141 - 159, 2025. DOI: 10.13189/app.2025.130201.

(b). APA Format:
Duygu Alpaslan , Tuba Erşen Dudu , Busra Moran Bozer , Nahit Aktas , Mustafa Turk (2025). Poly(CnO) and Poly(CcO) Organo-Particles Produced from Coconut Oil (CnO) and Cocoa Oil (CcO): Synthesis, Characterization, Bio and Anticancer Activity. Advances in Pharmacology and Pharmacy, 13(2), 141 - 159. DOI: 10.13189/app.2025.130201.