International Journal of Biochemistry and Biophysics Vol. 1(1), pp. 16 - 21
DOI: 10.13189/ijbb.2013.010103
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Lipid Peroxidation and Antioxidant System Activity Changes of Rat Blood and Cardiac Muscle Cells Under Chronic Stress

Natalia Dachanidze^*, George Burjanadze, Zurab Kuchukashvili, Ketevan Menabde, Nana Koshoridze
Department of Biology, Faculty of Exact and Natural Sciences, Iv. Javakhishvili Tbilisi State University, Tbilisi 0128, Georgia

ABSTRACT

We studied the functionality of the antioxidant system in laboratory rat cardiac muscle cells and blood under psycho-emotional stress. It was found that 40-day isolation and violation of diurnal cycle among the animals were accompanied by the intensification of lipid per oxidation process shown by a rise in the quantity of one of the primary and final products of this process – diene conjugates and thiobarbituric acid active compounds, including malonedialdehydes and marked with a reduced activity of antioxidant system enzymes, such as catalase and superoxide dismutase activity. Based on the results, we pro-posed that psychological stress is one of the factors contributing to the development of various cardiac diseases.

KEYWORDS
Nitric Oxide, Cardiac Muscle Cells, Lipid Per Oxidation, Stress, Superoxide-dismutase, Catalase

Cite This Paper in IEEE or APA Citation Styles
(a). IEEE Format:
[1] Natalia Dachanidze , George Burjanadze , Zurab Kuchukashvili , Ketevan Menabde , Nana Koshoridze , "Lipid Peroxidation and Antioxidant System Activity Changes of Rat Blood and Cardiac Muscle Cells Under Chronic Stress," International Journal of Biochemistry and Biophysics, Vol. 1, No. 1, pp. 16 - 21, 2013. DOI: 10.13189/ijbb.2013.010103.

(b). APA Format:
Natalia Dachanidze , George Burjanadze , Zurab Kuchukashvili , Ketevan Menabde , Nana Koshoridze (2013). Lipid Peroxidation and Antioxidant System Activity Changes of Rat Blood and Cardiac Muscle Cells Under Chronic Stress. International Journal of Biochemistry and Biophysics, 1(1), 16 - 21. DOI: 10.13189/ijbb.2013.010103.