Universal Journal of Public Health Vol. 11(6), pp. 961 - 969
DOI: 10.13189/ujph.2023.110621
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Prevalence of High-risk Human Papillomaviruses and Associated Factors in Women Living with HIV and Followed at the Outpatient Treatment Center in Brazzaville, Congo

Maryse N. Akolbout-Manguilla ^1,2,*, Edith-Sophie Kombo Bayonne ¹, Norcely Makela ², Valchy Miegakanda ³, Laure Ghoma Linguissi ⁴, Rocide Moukouba ², Merlin Isidore Diafouka ², Jean Félix Peko ^1,5
1 Faculty of Health Sciences, Marien Ngouabi University, Congo
² Outpatient Treatment Center, Brazzaville, Congo
³ National Public Health Laboratory, Brazzaville, Congo
⁴ National Institute for Health Sciences Research, Brazzaville, Congo
⁵ University Hospital Center, Brazzaville, Congo

ABSTRACT

Genital Human Papillomavirus infection and HIV infection are both sexually transmitted infections. High-risk genotypes (HR-HPV) predispose patients to cancer development. This study aims to determine the prevalence of HR-HPV in cervix specimens and to identify factors associated with the presence of HR-HPV in women living with HIV (WLHIV). This was a cross-sectional study conducted from April 2021 to March 2022 at the Outpatient Treatment Center, and at the National Public Health Laboratory in Brazzaville. WLHIV aged over 17 years were included. Socio-demographic data, history, clinical data, and biological data were collected. The identification of HR-HPV genotypes was performed from endocervix samples by the real-time PCR technique. Statistical analyses were carried out using SPSS Statistics software. A total of 276 WLHIV were enrolled. The mean age was 44.6 (SD 8.9) years. The prevalence of HR-HPV was 44.2%. In multivariate analysis, the level of primary education (p=0.034; CI 95%; ORa=2.62 [1.07–6.39]) was identified as a factor associated with HPV/HIV co-infection, and a CD4 count greater than or equal to 200 cells/mm³ as a protective factor against HR-HPV infection (p=0.04; CI 95%; ORa=0.28 [0.07-0.87]). This study reveals a high prevalence of HR-HPV among WLHIV. It shows a significant association between the low level of education and genital infection by HR-HPV, as well as the protective role of the CD4 count greater than 200/mm³, in this population group. This suggests the establishment of a systematic screening of HPV-HR in women affected by HIV and the strengthening of preventive measures for sexually transmitted infections. The means of communication used for prevention must be adapted to the target populations' level of education.

KEYWORDS
Prevalence, High-risk Human Papillomavirus, HIV, Sexually Transmitted Diseases, Realtime PCR, Congo

Cite This Paper in IEEE or APA Citation Styles
(a). IEEE Format:
[1] Maryse N. Akolbout-Manguilla , Edith-Sophie Kombo Bayonne , Norcely Makela , Valchy Miegakanda , Laure Ghoma Linguissi , Rocide Moukouba , Merlin Isidore Diafouka , Jean Félix Peko , "Prevalence of High-risk Human Papillomaviruses and Associated Factors in Women Living with HIV and Followed at the Outpatient Treatment Center in Brazzaville, Congo," Universal Journal of Public Health, Vol. 11, No. 6, pp. 961 - 969, 2023. DOI: 10.13189/ujph.2023.110621.

(b). APA Format:
Maryse N. Akolbout-Manguilla , Edith-Sophie Kombo Bayonne , Norcely Makela , Valchy Miegakanda , Laure Ghoma Linguissi , Rocide Moukouba , Merlin Isidore Diafouka , Jean Félix Peko (2023). Prevalence of High-risk Human Papillomaviruses and Associated Factors in Women Living with HIV and Followed at the Outpatient Treatment Center in Brazzaville, Congo. Universal Journal of Public Health, 11(6), 961 - 969. DOI: 10.13189/ujph.2023.110621.