Advances in Zoology and Botany Vol. 12(1), pp. 47 - 62
DOI: 10.13189/azb.2024.120106
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Select Phytocompounds from Cocculus hirsutus (L.) W. Theob. Extract Having Anti-Cancer Potential as Identified by LC-MS and in Silico Studies

N. R. Salve ^1,*, D. N. Mishra ^2
1 Department of Botany, Jamkhed Mahavidyalaya Jamkhed, India
² Punyashlok Ahilyadevi Holkar Solapur University, Solapur, Maharashtra, India

ABSTRACT

Cancer is one of the leading causes of mortality worldwide. The metabolites of plant sources have been revealing great promise to treat cancers, too. The anticancer potentials of several medicinal plants are now being studied, although ancient medical systems treated patients of such kind. New directions in cancer research are now possible due to modern developments in biological sciences. In view of various recognised therapeutic properties of Cocculus, the plant is utilised in the indigenous systems of medicines to treat a wide variety of diseases. Many important secondary metabolites from Cocculus hirsutus (L.) W. Theob. plant have been reported by earlier workers. The previous studies and findings on anticancer activity of crude extract of this plant, encourage to further investigate the Phyto/bio-compounds of the extracts with Liquid Chromatography-Mass Spectroscopy (LC-MS) technique and by using in-silico tool to make rational correlations of the properties. By LC-MS technique, phytocompounds were identified from the crude methanolic extract of Cocculus hirsutus. Chemoinformatics tools were employed to screen the phytocompounds and predict the potential anticancer activities of these compounds. Through modern tool like in-silico virtual screening software, the potentials of such phytocompounds as drugs and as leads against cancer disease were investigated. The comparative analysis was made between the known activities of the highly used/ approved/standard anticancer plant-derived drugs and the predicted activities of the fifteen compounds identified from the extract that were under investigation. In terms of activity, these compounds closely resemble to the approved/standard/recognised plant-derived anticancer drugs. The compounds like the 2,3-Dihydrogossypetin, Trilostane, Nonanoic acid, Irinotecan, Euphornin, Salannin and Gnididilatin are predicted to have drug-likeness. These findings would help reaching the desired target-based medicines for the dreaded disease like cancer. Irinotecan, the semi-synthetic Camptothecin alkaloid, an approved/standard anti-cancer agent (having Topoisomerase I inhibitor activity), is reported for the first time from natural source, like Cocculus hirsutus plant. This plant is in the list of ethnomedicines too and can be considered as a potential source of a drug candidate for the treatment of various types of cancers.

KEYWORDS
Cancer, Camptothecin Derivative, Irinotecan, Antitumor, Anticarcinogenic, Antineoplastic, Chemoprotective, Chemopreventive, Carcinoma, Cocculus Hirsutus

Cite This Paper in IEEE or APA Citation Styles
(a). IEEE Format:
[1] N. R. Salve , D. N. Mishra , "Select Phytocompounds from Cocculus hirsutus (L.) W. Theob. Extract Having Anti-Cancer Potential as Identified by LC-MS and in Silico Studies," Advances in Zoology and Botany, Vol. 12, No. 1, pp. 47 - 62, 2024. DOI: 10.13189/azb.2024.120106.

(b). APA Format:
N. R. Salve , D. N. Mishra (2024). Select Phytocompounds from Cocculus hirsutus (L.) W. Theob. Extract Having Anti-Cancer Potential as Identified by LC-MS and in Silico Studies. Advances in Zoology and Botany, 12(1), 47 - 62. DOI: 10.13189/azb.2024.120106.