Universal Journal of Public Health Vol. 11(6), pp. 861 - 868
DOI: 10.13189/ujph.2023.110610
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Centella asiatica (Indian Pennywort) Extract and Exercise Increase Brain-Derived Neurotrophic Factor Plasma, Cognition, and Physical Fitness among Menopausal Women

Iwan Setiawan ^1,2,*, Lisna Anisa Fitriana ³, I Ketut Adnyana ⁴, Kusnandar Anggadiredja ⁴, Nazhifa Ufamy ⁴, Irma Darmawati ³, Lina Anisa Nasution ³, Suci Tuty Putri ³, Upik Rahmi ³, Septian Andriyani ³, Komarudin ⁵, Ria Maria Theresa ⁶, Aih Cahyani ^7
1 Center for Sport Science, Wellness, and Longevity, the Graduate School of Universitas Padjadjaran, Indonesia
² Department of Biomedical Science, Faculty of Medicine, Universitas Padjadjaran, Indonesia
³ Department of Nursing, Faculty of Sport and Health Education, Universitas Pendidikan Indonesia, Bandung, Indonesia
⁴ Department of Pharmacology and Clinical Pharmacy, School of Pharmacy, Institut Teknologi Bandung, Bandung, Indonesia
⁵ Department of Sport Coaching Education, Faculty of Sport and Health Education, Universitas Pendidikan Indonesia, Bandung, Indonesia
⁶ Department of Psychiatry, Faculty of Medicine, Universitas Pembangunan Nasional Veteran, Jakarta, Indonesia
⁷ Department of Neurology, Hasan Sadikin Hospital, Bandung, Indonesia

ABSTRACT

Menopausal women are prone to cognitive disorders. Various therapies that have been developed to overcome this problem are the administration of Indian Pennywort (Centella asiatica) and exercise. Both have positive effects on cognitive function, but previous studies have not examined the combined effect of the two on the brain-derived neurotrophic factor (BNDF), cognition, and physical fitness among menopausal women. Methods: This study used a pre and post-test design. Subjects consisted of 64 people who were divided into four groups, consisting Indian pennywort/IP group (500 mg daily), an exercise group (2x90 minutes per week), a group combination of IP-exercise (IP 500 mg daily and exercise for 2x90 minutes per week), and the control group. The intervention was given for 12 weeks. Results: The study showed that Indian Pennywort, exercise, and its combination can increase plasma BDNF, cognition, and physical fitness in menopausal women (p<0.05). Mann-Whitney test showed that the combination of Indian Pennywort and exercise caused the highest increase in plasma BDNF (∆=236; p=0.007), MoCA (∆=3.5; p<0.001), right-hand strength (∆ =4.6; p=0.001), left-hand strength (∆=3.5; p=0.001), and lower extremity strength (∆=6; p<0.001). Conclusion: Overall results showed that Indian Pennywort, exercise, and the combination of the two above were effective in ameliorated plasma BDNF, cognition, and physical fitness in menopausal women, but the combination provides a maximum effect compared to other groups.

KEYWORDS
BDNF, Cognition, Exercise, Centella Asiatica, Physical Fitness

Cite This Paper in IEEE or APA Citation Styles
(a). IEEE Format:
[1] Iwan Setiawan , Lisna Anisa Fitriana , I Ketut Adnyana , Kusnandar Anggadiredja , Nazhifa Ufamy , Irma Darmawati , Lina Anisa Nasution , Suci Tuty Putri , Upik Rahmi , Septian Andriyani , Komarudin , Ria Maria Theresa , Aih Cahyani , "Centella asiatica (Indian Pennywort) Extract and Exercise Increase Brain-Derived Neurotrophic Factor Plasma, Cognition, and Physical Fitness among Menopausal Women," Universal Journal of Public Health, Vol. 11, No. 6, pp. 861 - 868, 2023. DOI: 10.13189/ujph.2023.110610.

(b). APA Format:
Iwan Setiawan , Lisna Anisa Fitriana , I Ketut Adnyana , Kusnandar Anggadiredja , Nazhifa Ufamy , Irma Darmawati , Lina Anisa Nasution , Suci Tuty Putri , Upik Rahmi , Septian Andriyani , Komarudin , Ria Maria Theresa , Aih Cahyani (2023). Centella asiatica (Indian Pennywort) Extract and Exercise Increase Brain-Derived Neurotrophic Factor Plasma, Cognition, and Physical Fitness among Menopausal Women. Universal Journal of Public Health, 11(6), 861 - 868. DOI: 10.13189/ujph.2023.110610.