Advances in Zoology and Botany Vol. 11(4), pp. 246 - 256
DOI: 10.13189/azb.2023.110402
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Small Heat Shock Protein and Drosophila melanogaster Development

Shreya Tripathi ¹, Sangeeta Sinha ^2,*
1 Department of Zoology, Asutosh College, Calcutta University, India
² Department of Zoology, Nowrosjee Wadia College, Pune, India

ABSTRACT

To understand the regulation and function of the heat shock response, Drosophila model system has been used for the past few decades. Drosophila heat shock protein is a family of proteins which show large changes in their expression pattern upon deviation from optimal temperature of organism in either direction, thereby preventing cells from potential damages. Small heat shock protein (sHsp) is a subfamily under this family and is known for its role in a wide variety of cellular functions (ageing, immunity, proteotoxicity, apoptosis, etc.) apart from maintaining homeostasis. In all domains of drosophila life cycle, ATP-independent stress proteins i.e. small heat shock proteins (sHsps) are found. The review highlights the various roles played by different members of sHsp in Drosophila melanogaster and their contribution to ageing and autophagy. Some members of the subfamily also show differential localization in different organelles and tissues, at different developmental stages as well as in adults owing to their functions. For understanding protein function, determination and localization of cellular proteins was studied. Determining the cellular localization of proteins is important for understanding protein functions. Some of the Hsps are up-regulated in organ and tissue-specific manner which help to understand life span and different biomarkers during the course of Drosophila life cycle. Some of the members of small heat shock protein in Drosophila melanogaster are orthologs of human sHsp and hence can serve as a good model for studying diseases in humans associated with members of this subfamily. Different parameters and tools can be used experimentally which will help in manipulating gene function and determining health span in Drosophila. This provides an unparalleled opportunity to further study the role of sHsps.

KEYWORDS
Drosophila melanogaster, Small Heat Shock Proteins, Proteotoxicity, Aging, Homeostasis

Cite This Paper in IEEE or APA Citation Styles
(a). IEEE Format:
[1] Shreya Tripathi , Sangeeta Sinha , "Small Heat Shock Protein and Drosophila melanogaster Development," Advances in Zoology and Botany, Vol. 11, No. 4, pp. 246 - 256, 2023. DOI: 10.13189/azb.2023.110402.

(b). APA Format:
Shreya Tripathi , Sangeeta Sinha (2023). Small Heat Shock Protein and Drosophila melanogaster Development. Advances in Zoology and Botany, 11(4), 246 - 256. DOI: 10.13189/azb.2023.110402.