Advances in Zoology and Botany Vol. 11(3), pp. 226 - 238
DOI: 10.13189/azb.2023.110309
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To Evaluate Anti-Arthritic Potential of Syzygium samarangense Plant Extracts in Wistar Rats


Drashti Mandlik 1, Tanvi Desai 1,*, Binal Patel 1, Vijay Lambole 2, Vipul Gajera 1
1 Shree Naranjibhai Lalbhai Patel College of Pharmacy, India
2 Department of Pharmacology, Datta Meghe College of Pharmacy, India

ABSTRACT

Rheumatoid arthritis (RA) is a long-lasting infection, which can distress many of the organs and tissues but mainly affect the joints. The occurrence of RA may relate to changes in various hormones, genetics as well as environmental features. The existing work was performed for the investigation of Anti-arthritic action of Methanolic extract of Syzygium samarangense leaves (MESL) as well as roots (MESR) in Freund's complete adjuvant (CFA) induced arthritis in rats. For this study, MESL & MESR were prepared and subjected to phytochemical analysis as well as tested against CFA injected RA in rats on two dosage levels of 100 as well as 200 mg/kg of weight of body. Various parameters such as body weight, paw volume, arthritis index, hematological, histopathological as well as antioxidant parameters were evaluated for anti- arthritic activity of extracts. MESL and MESR showed anti-arthritic activity in dose-related means, by decreasing the volume of paw along with increasing the weight, while comparing with control group. MESL (100 and 200mg/kg) and MESR (100 and 200mg/kg) exhibited significant anti-arthritic action through elevating the level of Hemoglobin, RBC as well as a declining number of Platelets, WBC, Erythrocyte Sedimentation Rate, C-Reactive Protein along with Rheumatoid Factor. The higher and lower doses of both extracts showed decreases in oxidative stress in dose-related means compared to control group. The result of histopathological analysis showed that MESL (100 and 200mg/kg) and MESR (100 and 200mg/kg) reduce ankle joint destruction. Results of different parameters also showed that MESL has higher potency to decrease arthritis compared to MESR.

KEYWORDS
Antioxidant, Freund's Complete Adjuvant, Jambu, Rheumatoid Arthritis, Rheumatoid Factor, Syzygium samarangense

Cite This Paper in IEEE or APA Citation Styles
(a). IEEE Format:
[1] Drashti Mandlik , Tanvi Desai , Binal Patel , Vijay Lambole , Vipul Gajera , "To Evaluate Anti-Arthritic Potential of Syzygium samarangense Plant Extracts in Wistar Rats," Advances in Zoology and Botany, Vol. 11, No. 3, pp. 226 - 238, 2023. DOI: 10.13189/azb.2023.110309.

(b). APA Format:
Drashti Mandlik , Tanvi Desai , Binal Patel , Vijay Lambole , Vipul Gajera (2023). To Evaluate Anti-Arthritic Potential of Syzygium samarangense Plant Extracts in Wistar Rats. Advances in Zoology and Botany, 11(3), 226 - 238. DOI: 10.13189/azb.2023.110309.