International Journal of Biochemistry and Biophysics Vol. 10(3), pp. 25 - 31
DOI: 10.13189/ijbb.2022.100301
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Therapeutically Active Marine Sponge Isolated from Rameshwaram Thoppu Kaadu Theevu against MDR Pathogen Lactobacillus acidophilus Isolated from Childhood Caries

S. Vijayalakshmi ^1,*, A. Mohankumar ^2
1 HOD i/c, PG and Research Department of Zoology, Vivekanandha College of Arts and Sciences for Women (Autonomous), Tiruchengode - 637 205, Tamilnadu, India
² Assistant Professor, PG and Research Department of Zoology, Chikkanna Govt. Arts College, Tirupur – 641 602, Tamil Nadu, India

ABSTRACT

Dental illness is a foremost health problem upsetting childhood, and this action severely causes sickness which is caused by emerging pathogen Lactobacillusacidophilus. So plaque samples were collected from diverse dental clinics around Tirupur Dt. In this study, 20 MDR isolates were isolated and identified by biochemical analysis. Additionally, the decay pathogen Lactobacillus acidophilus was assayed against Levofloxacin, Moxifloxacin, Clindamycin, Vancomycin, Ampicillin, Chloramphenicol, Tetracycline and Novobiocin. Among these strains 0%, 0%, 26%, 34%, 22%, 2%, 16%, 16% and 6% were found to exhibit resistance to four groups of antibiotics. Currently, the extension of resistance to contemporary antimicrobials has demand to search for innovative anti-therapeutic agent. Moreover, several studies mostly deal with marine sponge to explore the therapeutic drug and this potential role in the manufacture of metabolites is becoming a driving area for exploring a rich source of novel compounds that are of prospective interest to mankind for diagnosis of tooth decay. Different concentration of sponge 50μg, 100μg, and 150μg were prepared with DMSO, and well diffusion assay was used. The result indicated that the maximum and minimum inhibition of 22 mm and 16 mm was observed against the isolate LAVG07 and LAVG08. This research proved that the marine sponge extract shows the prominent antimicrobial activity against decay causing organism and it may be broadcast to be a successful approach to come to blow promising multi challenging clinical drugs in the future.

KEYWORDS
Dental Caries, Lactobacillus acidophilus, Antibiotic Susceptibility, Plasmid, Marine Sponge

Cite This Paper in IEEE or APA Citation Styles
(a). IEEE Format:
[1] S. Vijayalakshmi , A. Mohankumar , "Therapeutically Active Marine Sponge Isolated from Rameshwaram Thoppu Kaadu Theevu against MDR Pathogen Lactobacillus acidophilus Isolated from Childhood Caries," International Journal of Biochemistry and Biophysics, Vol. 10, No. 3, pp. 25 - 31, 2022. DOI: 10.13189/ijbb.2022.100301.

(b). APA Format:
S. Vijayalakshmi , A. Mohankumar (2022). Therapeutically Active Marine Sponge Isolated from Rameshwaram Thoppu Kaadu Theevu against MDR Pathogen Lactobacillus acidophilus Isolated from Childhood Caries. International Journal of Biochemistry and Biophysics, 10(3), 25 - 31. DOI: 10.13189/ijbb.2022.100301.