Universal Journal of Public Health Vol. 10(1), pp. 138 - 144
DOI: 10.13189/ujph.2022.100115
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Exercise Moderate Interval as an Alternative Exercise Model to Improve Insulin Sensitivity in Type 2 Diabetes Mellitus

Yetty Machrina ^1,*, Ambrosius Purba ², Dwi Rita Anggraini ^3
1 Department of Physiology, Faculty of Medicine, Universitas Sumatera Utara, Indonesia
² Department of Physiology, Faculty of Medicine, Universitas Padjajaran, Indonesia
³ Department of Anatomy, Faculty of Medicine, Universitas Sumatera Utara, Indonesia

ABSTRACT

Background: Previous study had found that adherence of patient Diabetes type-2 in moderate to vigorous continuous exercise was poor. Meanwhile regularly exercise needs to control fasting plasma glucose in T2DM. Exercise moderate interval (EMI) shows a significant effect to reduce insulin resistance in metabolic syndrome patients. But, studies to find the effect of EMI or EMC to muscle insulin receptor distribution are still limited. So, the purpose of this study is to compare the effects of EMI vs EMC in increasing insulin receptors and reducing insulin resistance in T2DM rat models. Methods: An experimental study was conducted in T2DM rat models. According to the treatments, rats were randomly assigned into the following 3 groups: sedentary group (SG), exercise moderate continuous (EMC) and exercise moderate interval (EMI). Each training session was performed on treadmill for eight weeks, three times weekly. Insulin receptor was assessed by immunohistochemistry. Meanwhile, insulin resistance was determined by Homeostatic Model Assessment for Insulin (HOMA-IR) score measured before and after completing the training session. Results: This study found that the insulin receptors in EMI = 184% and EMC= 158%. Both insulin receptors in the treatment groups had a significant difference to the sedentary group (p=0.002), but there was no significant difference in insulin receptors between EMI and EMC group (p=0.222). HOMA-IR in EMI group was 16.6±4.0 significantly different with HOMA-IR in EMC group such as 43.3±8.6 (p=0.000). There was a negative correlation between insulin receptor and insulin resistance (p=0.047, r =-0.520). Conclusion: Both exercise moderate interval and exercise moderate continuous could increase insulin receptors on skeletal muscle, but exercise moderate interval showed better improve insulin sensitivity after eight weeks' exercise. We suggested exercise moderate interval as an alternative exercise for Type 2 Diabetes Mellitus.

KEYWORDS
Insulin Receptor, Insulin Resistance, Exercise Moderate Interval, Exercise Moderate Continuous

Cite This Paper in IEEE or APA Citation Styles
(a). IEEE Format:
[1] Yetty Machrina , Ambrosius Purba , Dwi Rita Anggraini , "Exercise Moderate Interval as an Alternative Exercise Model to Improve Insulin Sensitivity in Type 2 Diabetes Mellitus," Universal Journal of Public Health, Vol. 10, No. 1, pp. 138 - 144, 2022. DOI: 10.13189/ujph.2022.100115.

(b). APA Format:
Yetty Machrina , Ambrosius Purba , Dwi Rita Anggraini (2022). Exercise Moderate Interval as an Alternative Exercise Model to Improve Insulin Sensitivity in Type 2 Diabetes Mellitus. Universal Journal of Public Health, 10(1), 138 - 144. DOI: 10.13189/ujph.2022.100115.