Advances in Pharmacology and Pharmacy Vol. 7(1), pp. 5 - 13
DOI: 10.13189/app.2019.070102
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Neurobehavioural Mechanism of Antidepressant Effect of Methanol Stem Bark Extract of Adansonia digitata (Linn) in Tail Suspension Test in Mice


Akinpelu Lateef Abiola 1,*, Adebayo Muritala Ayofe 2, Adesola Adedoyin 1
1 Department of Pharmacology and Toxicology, Dora Akunyili College of Pharmacy, Igbinedion University, Nigeria
2 Department of Pharmacognosy, Dora Akunyili College of Pharmacy, Igbinedion University, Nigeria

ABSTRACT

Aim: An earlier study has demonstrated the in-vivo antidepressant effect of methanol stem bark extract of Adansonia digitata, using soxhlet extraction protocol, but there is a lack of scientific data on its neurobehavioural mechanism of action. This study, therefore, investigated its antidepressant potentials, using cold maceration method, and determined the probable neurobehavioural mechanism of its antidepressant-like effect. Methodology: The antidepressant-like effect of the extract was evaluated in tail suspension test, at graded doses in mice. Subsequently, the probable neurobehavioural mechanism of the antidepressant-like effect of the extract was investigated by intraperitoneal pretreatment with adrenergic, serotonergic, dopaminergic, and muscarinic cholinergic receptor antagonists; GABA agonist; nitric oxide precursor and inhibitors; and using a putative neuromodulator at NMDA receptors prior to the extract administration. Results and discussion: The extract at all the doses used, significantly (p<0.05) and dose-dependently decreased the immobility time in tail suspension test without significant (p>0.05) alteration on locomotor behaviour in mice. However, the anti-immobility potential of the extract was significantly (p<0.05) reversed by prazosin, yohimbine, sulpiride, methylene blue, L-arginine and baclofen, suggesting the involvement of adrenergic, dopaminergic, GABAerargic and nitergic pathways. Conclusion: This study, therefore, concluded that the extract may possess antidepressant effect and its mechanism may involve multiple pathways.

KEYWORDS
Adansonia digitata, Cold Maceration, Antidepressant, Neurobehavioural Mechanism, Multiple Receptor Pathways

Cite this paper
Akinpelu Lateef Abiola , Adebayo Muritala Ayofe , Adesola Adedoyin . "Neurobehavioural Mechanism of Antidepressant Effect of Methanol Stem Bark Extract of Adansonia digitata (Linn) in Tail Suspension Test in Mice." Advances in Pharmacology and Pharmacy 7.1 (2019) 5 - 13. doi: 10.13189/app.2019.070102.