International Journal of Biochemistry and Biophysics Vol. 6(4), pp. 77 - 82
DOI: 10.13189/ijbb.2018.060401
Reprint (PDF) (185Kb)


Evaluation of Anti-inflammatory Activity of Crinum scillifolium Extracts in Wistar Rats


Koua Kadio Brou Donald 1,*, Irié-N’guessan Amenan Geneviève 2, Effo Kouakou Etienne 2, Kouakou Sylvain Landry 2, Ayoman Thierry Lenoir djadji 2, Tetchi Achille Fabrice 3, Yapi Houphouët Felix 1
1 Laboratory of Biochemical Pharmacodynamics, UFR Biosciences, Felix Houphouët-Boigny University, Côte d'Ivoire
2 Department of Pharmacology, Clinical and Therapeutical Pharmacy UFR Pharmaceutical and Biologic Sciences, Felix Houphouët-Boigny University, Côte d'Ivoire
3 Laboratory of Food Biochemistry and Tropical Products Technology, University of Nangui Abrogoua, Côte d'Ivoire

ABSTRACT

Aim of study: Inflammation was associated with many diseases in humans. Crinum species have a considerable medicinal reputation as potent folkloric remedies. The main objective of the study was to evaluate the anti-inflammatory activity of aqueous and hydroethanolic extracts of Crinum scillifolium bulbs in in vivo models. Materials and methods: The anti-inflammatory effect of Crinum scillifolium extracts was also evaluated in carrageenan-induced paw edema models and C-reactive protein (CRP) levels was measured. Two doses 100 and 200 mg/kg body weight for each extract, were tested. The results obtained were compared with those of the standard drug (Diclofenac at 25 mg/kg body weight) and those of the control (normal saline). Results: The results showed a highly significant decrease in the edema size (p < 0.01) and significant decrease in CRP values (p < 0.01) compared to control group when the animals were treated with diclofenac at 25 mg/kg, and 200 mg/kg of aqueous and hydroethanolic extracts. Conclusion: The study suggests that the extracts possess enough potential to reduce inflammation on rat model and directs the importance of further research and development of novel anti-inflammatory agents.

KEYWORDS
Crinum scillifolium, Inflammation, CRP, Carrageenan

Cite This Paper in IEEE or APA Citation Styles
(a). IEEE Format:
[1] Koua Kadio Brou Donald , Irié-N’guessan Amenan Geneviève , Effo Kouakou Etienne , Kouakou Sylvain Landry , Ayoman Thierry Lenoir djadji , Tetchi Achille Fabrice , Yapi Houphouët Felix , "Evaluation of Anti-inflammatory Activity of Crinum scillifolium Extracts in Wistar Rats," International Journal of Biochemistry and Biophysics, Vol. 6, No. 4, pp. 77 - 82, 2018. DOI: 10.13189/ijbb.2018.060401.

(b). APA Format:
Koua Kadio Brou Donald , Irié-N’guessan Amenan Geneviève , Effo Kouakou Etienne , Kouakou Sylvain Landry , Ayoman Thierry Lenoir djadji , Tetchi Achille Fabrice , Yapi Houphouët Felix (2018). Evaluation of Anti-inflammatory Activity of Crinum scillifolium Extracts in Wistar Rats. International Journal of Biochemistry and Biophysics, 6(4), 77 - 82. DOI: 10.13189/ijbb.2018.060401.