International Journal of Biochemistry and Biophysics Vol. 5(2), pp. 46 - 52
DOI: 10.13189/ijbb.2017.050202
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Evaluation of Doses-response and Combined Preventive Effects of Zinc and Vitamin D on Liver Toxicity Induced by Carbon Tetrachloride in Wistar Rats


Serge D. Kone 1, Francis A. Yapo 1,*, Goue Gnahoue 2, Felix H. Yapi 1
1 Pharmacodynamics Biochemical Laboratory, UFR Biosciences, Felix Houphouet-Boigny University, Côte d'Ivoire
2 Laboratory of SVT, Higher Teacher Training School of Cote d'Ivoire, Cote d'Ivoire

ABSTRACT

Severe hepatic insufficiency caused by a toxic is a strong danger to the individual survival. Zinc and vitamin D are micronutrients involved in the prevention of several diseases. Our study was to evaluate the potential preventive effects of these micronutrients in hepatic toxicity induced by carbon tetrachloride (CCl4) in rats. One hundred and fourteen (114) male rats were divided into 19 lots of 6 male rats each according to their body weight. Carbon tetrachloride (CCl4) was used to induce hepatic toxicity in rats. The rats were treated respectively with 25, 50 and 100 mg/kg of zinc and 6, 12 and 24μg/kg of Vitamin D and also with the combination of zinc and Vitamin D at the same concentrations. There was a significant increase in serum of ALT, AST without changing Total Protein level in the serum of rats treated with CCl4 compared to rats in the control lots. However, Zinc and Vitamin D supplementation caused a significant decrease in serum of ALT and AST activity without changing Total Protein concentration in the serum of rats. This study revealed that that zinc combined with Vitamin D could be a good protection against hepatic toxicity induced by chemicals.

KEYWORDS
Hepatoprotective, Zinc, Vitamin D, Hepatic Toxicity, Rat

Cite This Paper in IEEE or APA Citation Styles
(a). IEEE Format:
[1] Serge D. Kone , Francis A. Yapo , Goue Gnahoue , Felix H. Yapi , "Evaluation of Doses-response and Combined Preventive Effects of Zinc and Vitamin D on Liver Toxicity Induced by Carbon Tetrachloride in Wistar Rats," International Journal of Biochemistry and Biophysics, Vol. 5, No. 2, pp. 46 - 52, 2017. DOI: 10.13189/ijbb.2017.050202.

(b). APA Format:
Serge D. Kone , Francis A. Yapo , Goue Gnahoue , Felix H. Yapi (2017). Evaluation of Doses-response and Combined Preventive Effects of Zinc and Vitamin D on Liver Toxicity Induced by Carbon Tetrachloride in Wistar Rats. International Journal of Biochemistry and Biophysics, 5(2), 46 - 52. DOI: 10.13189/ijbb.2017.050202.