International Journal of Cardiovascular and Cerebrovascular Disease Vol. 5(1), pp. 1 - 7
DOI: 10.13189/ijccd.2017.050101
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Evaluation of Antihypertensive Activity of Aqueous and Ethylic Alcohol Extracts of Stem Bark of Xylopia villosa Chipp (Annonaceae)


Kouame Yao Yves 1,*, Okpekon Aboua Timothée 2, Yapi Houphouët Félix 1
1 Laboratory of Pharmacodynamics Biochemical, UFR Biosciences, Felix Houphouet Boigny University, Côte d'Ivoire
2 Laboratory of Organic Chemistry and Natural Substances, UFR Sciences of Structures of Matter and Technology, Felix Houphouet Boigny University, Côte d'Ivoire

ABSTRACT

This study aims to evaluate Antihypertensive activity of aqueous and ethanolic extracts of Xylopia villosa stem bark. The induction of hypertension was made with adrenaline on albino rats of wistar strain. Treatments of hypertensive rats with aqueous and ethanolic extracts of Xylopia villosa at doses of 100 and 200 mg/kg bw and Atenolol (the reference molecule) at doses of 10 and 20 mg/kg bw have normalized cardiovascular parameters such as systolic blood pressure, diastolic blood pressure and heart rate. However, these doses all increased the blood concentration of Na+ of hypertensive rats. Only treatments with aqueous and ethanolic extracts at a dose of 200mg/kg bw were able to bring blood concentration in K+ of hypertensive rats to a concentration equivalent to that of normotensive rats.

KEYWORDS
Xylopia villosa, Adrenaline, Antihypertesive, Systolic Blood Pressure, Diastolic Blood Pressure, Heart Rate

Cite this paper
Kouame Yao Yves , Okpekon Aboua Timothée , Yapi Houphouët Félix . "Evaluation of Antihypertensive Activity of Aqueous and Ethylic Alcohol Extracts of Stem Bark of Xylopia villosa Chipp (Annonaceae)." International Journal of Cardiovascular and Cerebrovascular Disease 5.1 (2017) 1 - 7. doi: 10.13189/ijccd.2017.050101.