International Journal of Biochemistry and Biophysics Vol. 4(2), pp. 11 - 15
DOI: 10.13189/ijbb.2016.040201
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Hypolipidemic Effect of Hyphaene thebaica (Doum-palm) in Induced Hypercholestrolemic Wistar Albino Rats


Nema A. Elhaj 1, Nabiela M. ElBagir 2,*
1 Faculty of Pharmacy, Ahfad University College for Women, Sudan
2 Department of Biochemistry, Faculty of Veterinary Medicine, University of Khartoum, Sudan

ABSTRACT

This study is designed to investigate the effect of feeding the whole bulb (mesocarp) of Hyphaene thebaica fruit, as 3% of the diet, on lipid profile in Diet-induced hypercholesterolemic Wistar albino rats. Various dietary rations were prepared by addition of H. thepaica, to assess their impact on the serum triglycerides, total cholesterol and its fractions the LDL-C, HDL-C and VLDL-C in normal and induced hypercholestrolemic rats. The rats were divided into four groups and fed for three-weeks as follows: Group 1 fed basal rat diet, group 2 fed the basal rat diet mixed with H. thebaica, group 3 fed high fat diet (the basal rat diet mixed with, calculated amount of, egg yolk to formulate a diet of 1% cholesterol) and group 4 fed the high fat diet mixed with H. thebaica. By the end of the experiment a significant (P=0.03) increase in serum triglycerides and the VLDL-C was observed in groups (3 and 4) compared to the control group. Also the level of LDL-C increased significantly (P=0.04) in group 3 but decreased numerically in group 4. Moreover, the lowest level of the total cholesterol was recorded in group 2 compared to the other groups. However, feeding H. thebaica when mixed with high fat in the diet, resulted in significantly (P=0.02) decreased HDL-C levels. In conclusion this study suggested that H. thebaica contains active ingredients that can manipulate blood lipids and can protect from an increase of the bad cholesterol in the blood, even if a high fat diet is consumed. The present experiment also showed that, the increase of serum triglycerides and VLDL-C levels due to feeding high fat diet in group 3, was augmented by adding H. thebaica to the diet in group 4, so the study of the fatty acid composition of these lipid fractions is recommended.

KEYWORDS
Hyphaene thebaica, Lipid Profile Hypercholestrolemia

Cite This Paper in IEEE or APA Citation Styles
(a). IEEE Format:
[1] Nema A. Elhaj , Nabiela M. ElBagir , "Hypolipidemic Effect of Hyphaene thebaica (Doum-palm) in Induced Hypercholestrolemic Wistar Albino Rats," International Journal of Biochemistry and Biophysics, Vol. 4, No. 2, pp. 11 - 15, 2016. DOI: 10.13189/ijbb.2016.040201.

(b). APA Format:
Nema A. Elhaj , Nabiela M. ElBagir (2016). Hypolipidemic Effect of Hyphaene thebaica (Doum-palm) in Induced Hypercholestrolemic Wistar Albino Rats. International Journal of Biochemistry and Biophysics, 4(2), 11 - 15. DOI: 10.13189/ijbb.2016.040201.