International Journal of Biochemistry and Biophysics Vol. 4(1), pp. 4 - 9
DOI: 10.13189/ijbb.2016.040102
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Vibration Characteristics of Misfolded Proteins and Their Consquences


B.G. Majumder 1,*, Utpal Ch. De 2
1 State Resource Center, India
2 Department of Chemistry, Tripura University, India

ABSTRACT

The functioning of native protein has been discussed briefly. Disruption in native protein with misfolding in its structure due to infection or otherwise has also been discussed .The physical characteristics of prion- a variety of protein responsible for number of both degenerative and non-degenerative diseases have been detailed here from the view point of protein vibration due to external stimuli. Attempts have been taken to focus on the effects of charge groups on the surface of both folded and misfolded protein. Suggestion for application of magnetic materials which may be able to create potential barrier in controlling the chain process of infectious prions and other similar proteins have also been discussed basing on the frequencies of vibration of protein and also on the vibration energy thus evaluated.

KEYWORDS
Folded Protein, Misfolded Protein, Protein Aggregation, Prion Protein, Amyloid Disease, EEG Rhythms

Cite This Paper in IEEE or APA Citation Styles
(a). IEEE Format:
[1] B.G. Majumder , Utpal Ch. De , "Vibration Characteristics of Misfolded Proteins and Their Consquences," International Journal of Biochemistry and Biophysics, Vol. 4, No. 1, pp. 4 - 9, 2016. DOI: 10.13189/ijbb.2016.040102.

(b). APA Format:
B.G. Majumder , Utpal Ch. De (2016). Vibration Characteristics of Misfolded Proteins and Their Consquences. International Journal of Biochemistry and Biophysics, 4(1), 4 - 9. DOI: 10.13189/ijbb.2016.040102.