International Journal of Biochemistry and Biophysics Vol. 3(4), pp. 49 - 53
DOI: 10.13189/ijbb.2015.030401
Reprint (PDF) (518Kb)


Antitumor Drug Mitoxantrone Do Not Preclude Salt-driven B-Z Transition of Poly (dG- dC)


Armen T. Karapetyan *, Margarita A. Torosyan , Yurik S. Babayan
Department of Physics and Electrical Engineering, National University of Architecture and Construction of Armenia, Armenia

ABSTRACT

Despite of the existence in literature of large number of reports the binding modes of mitoxantrone (MTX) with DNA must be subject to refinement. Moreover there is no any report yet on interaction of MTX with Z-DNA. Here we present results of circular dichroism (CD) studies on MTX binding to salt driven left-handed conformation of poly(dG- dC). It was shown, that in contrast with classical intercalating ligands (ethidium bromide, acridine orange etc.) that bind with B-form DNA and obstacle B-Z transition at high concentrations of NaCl MTX interferes B-Z transition, but does not prevent the transitions process, thus suggest the semi intercalating (partial stacking) mode of MTX interaction with Z-form of DNA.

KEYWORDS
Mitoxantrone, Complexes MTX-poly(dG-dC), B-Z Transition of Complexes, Semi Intercalation

Cite This Paper in IEEE or APA Citation Styles
(a). IEEE Format:
[1] Armen T. Karapetyan , Margarita A. Torosyan , Yurik S. Babayan , "Antitumor Drug Mitoxantrone Do Not Preclude Salt-driven B-Z Transition of Poly (dG- dC)," International Journal of Biochemistry and Biophysics, Vol. 3, No. 4, pp. 49 - 53, 2015. DOI: 10.13189/ijbb.2015.030401.

(b). APA Format:
Armen T. Karapetyan , Margarita A. Torosyan , Yurik S. Babayan (2015). Antitumor Drug Mitoxantrone Do Not Preclude Salt-driven B-Z Transition of Poly (dG- dC). International Journal of Biochemistry and Biophysics, 3(4), 49 - 53. DOI: 10.13189/ijbb.2015.030401.