Advances in Diabetes and Metabolism Vol. 2(1), pp. 1 - 3
DOI: 10.13189/adm.2014.020101
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Insulin: Appropriate Placement in the Portal Vein

E. Dennis Murphy *
Department of Medicine, NorthShore University Health System University of Chicago Pritzker School of Medicine 2650 Ridge Avenue Evanston IL 60201


Subcutaneous insulin administration in the diabetic patient causes peripheral hyperinsulinemia, which contributes to vascular disease, hyperlipidemia and coagulation abnormalities. In the non diabetic patient, insulin is released from the pancreas into the portal system. The majority of this endogenous insulin is taken up by the liver in the first pass so that portal insulin exceeds peripheral insulin. Avoiding peripheral hyperinsulinemia requires that insulin be given orally or administered intra-portally; the latter we have done in diabetic dogs. We propose portal insulin placement in diabetes as physiologic and appropriate in an effort to avoid peripheral hyperinsulinemia and its sequellae.

Portal, Insulin, Placement

Cite this paper
E. Dennis Murphy (2014). Insulin: Appropriate Placement in the Portal Vein. Advances in Diabetes and Metabolism, 2 , 1 - 3. doi: 10.13189/adm.2014.020101.